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Repression of CENP-A assembly in metaphase requires HJURP phosphorylation and inhibition by M18BP1
Centromeres are the foundation for mitotic kinetochore assembly and thus are essential for chromosome segregation. Centromeres are epigenetically defined by nucleosomes containing the histone H3 variant CENP-A. CENP-A nucleosome assembly is uncoupled from replication and occurs in G1, but how cells...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165474/ https://www.ncbi.nlm.nih.gov/pubmed/37141119 http://dx.doi.org/10.1083/jcb.202110124 |