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Oxidation Driven Reversal of PIP(2)-dependent Gating in GIRK2 Channels

Physiological activity of G protein gated inward rectifier K(+) (GIRK, Kir3) channel, dynamically regulated by three key ligands, phosphoinositol-4,5-bisphosphate (PIP(2)), Gβγ, and Na(+), underlies cellular electrical response to multiple hormones and neurotransmitters in myocytes and neurons. In a...

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Detalles Bibliográficos
Autores principales:	Lee, Sun-Joo, Maeda, Shoji, Gao, Jian, Nichols, Colin G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165546/ https://www.ncbi.nlm.nih.gov/pubmed/37168492 http://dx.doi.org/10.1093/function/zqad016

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