Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

Pan-histone deacetylase (HDAC) inhibitors often have some toxic side effects. In this study, three series of novel polysubstituted N-alkyl acridone analogous were designed and synthesised as HDAC isoform-selective inhibitors. Among them, 11b and 11c exhibited selective inhibition of HDAC1, HDAC3, an...

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Detalles Bibliográficos
Autores principales: Wang, Ze, Zhao, Li, Zhang, Bo, Feng, Jiahe, Wang, Yule, Zhang, Bin, Jin, Haixiao, Ding, Lijian, Wang, Ning, He, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165928/
https://www.ncbi.nlm.nih.gov/pubmed/37144599
http://dx.doi.org/10.1080/14756366.2023.2206581

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