Cargando…

Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations

Gliomas are among the most common primary tumors of the brain. Discrimination among tumors of more than one focus has segregated the latter into two groups: multifocal gliomas and multicentric gliomas (MCGs). In this case series, outcomes among three patients are described and discussed in light of...

Descripción completa

Detalles Bibliográficos
Autores principales: Msheik, Ali, Fares, Youssef, Hamoud, Maarouf, Atat, Rami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165940/
https://www.ncbi.nlm.nih.gov/pubmed/37168179
http://dx.doi.org/10.7759/cureus.37284
_version_ 1785038344971878400
author Msheik, Ali
Fares, Youssef
Hamoud, Maarouf
Atat, Rami
author_facet Msheik, Ali
Fares, Youssef
Hamoud, Maarouf
Atat, Rami
author_sort Msheik, Ali
collection PubMed
description Gliomas are among the most common primary tumors of the brain. Discrimination among tumors of more than one focus has segregated the latter into two groups: multifocal gliomas and multicentric gliomas (MCGs). In this case series, outcomes among three patients are described and discussed in light of the findings present in the literature. Ideally, it is crucial to consider genetic testing for categorizing each tumor. This can help determine the original genetic mutations of MCGs and allow to establish necessary screening testing for early detection. We present the cases of three patients diagnosed with cranial gliomas. The first case showed two synchronous gliomas at different loci in the right hemisphere. The second patient showed synchronous lesions on cranial magnetic resonance imaging in each hemisphere. The third case was of a patient with metachronous lesions appearing at different times with similar radiological findings at different loci of the same hemisphere. Discrimination among multifocal and multicentric gliomas requires genetic workup because radiological and temporal findings may fail to allow adequate discrimination.
format Online
Article
Text
id pubmed-10165940
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-101659402023-05-09 Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations Msheik, Ali Fares, Youssef Hamoud, Maarouf Atat, Rami Cureus Neurology Gliomas are among the most common primary tumors of the brain. Discrimination among tumors of more than one focus has segregated the latter into two groups: multifocal gliomas and multicentric gliomas (MCGs). In this case series, outcomes among three patients are described and discussed in light of the findings present in the literature. Ideally, it is crucial to consider genetic testing for categorizing each tumor. This can help determine the original genetic mutations of MCGs and allow to establish necessary screening testing for early detection. We present the cases of three patients diagnosed with cranial gliomas. The first case showed two synchronous gliomas at different loci in the right hemisphere. The second patient showed synchronous lesions on cranial magnetic resonance imaging in each hemisphere. The third case was of a patient with metachronous lesions appearing at different times with similar radiological findings at different loci of the same hemisphere. Discrimination among multifocal and multicentric gliomas requires genetic workup because radiological and temporal findings may fail to allow adequate discrimination. Cureus 2023-04-08 /pmc/articles/PMC10165940/ /pubmed/37168179 http://dx.doi.org/10.7759/cureus.37284 Text en Copyright © 2023, Msheik et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Msheik, Ali
Fares, Youssef
Hamoud, Maarouf
Atat, Rami
Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations
title Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations
title_full Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations
title_fullStr Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations
title_full_unstemmed Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations
title_short Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations
title_sort unraveling the complexity of multicentric gliomas: insights into chronicity and genetic aberrations
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165940/
https://www.ncbi.nlm.nih.gov/pubmed/37168179
http://dx.doi.org/10.7759/cureus.37284
work_keys_str_mv AT msheikali unravelingthecomplexityofmulticentricgliomasinsightsintochronicityandgeneticaberrations
AT faresyoussef unravelingthecomplexityofmulticentricgliomasinsightsintochronicityandgeneticaberrations
AT hamoudmaarouf unravelingthecomplexityofmulticentricgliomasinsightsintochronicityandgeneticaberrations
AT atatrami unravelingthecomplexityofmulticentricgliomasinsightsintochronicityandgeneticaberrations