Cargando…
Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations
Gliomas are among the most common primary tumors of the brain. Discrimination among tumors of more than one focus has segregated the latter into two groups: multifocal gliomas and multicentric gliomas (MCGs). In this case series, outcomes among three patients are described and discussed in light of...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165940/ https://www.ncbi.nlm.nih.gov/pubmed/37168179 http://dx.doi.org/10.7759/cureus.37284 |
_version_ | 1785038344971878400 |
---|---|
author | Msheik, Ali Fares, Youssef Hamoud, Maarouf Atat, Rami |
author_facet | Msheik, Ali Fares, Youssef Hamoud, Maarouf Atat, Rami |
author_sort | Msheik, Ali |
collection | PubMed |
description | Gliomas are among the most common primary tumors of the brain. Discrimination among tumors of more than one focus has segregated the latter into two groups: multifocal gliomas and multicentric gliomas (MCGs). In this case series, outcomes among three patients are described and discussed in light of the findings present in the literature. Ideally, it is crucial to consider genetic testing for categorizing each tumor. This can help determine the original genetic mutations of MCGs and allow to establish necessary screening testing for early detection. We present the cases of three patients diagnosed with cranial gliomas. The first case showed two synchronous gliomas at different loci in the right hemisphere. The second patient showed synchronous lesions on cranial magnetic resonance imaging in each hemisphere. The third case was of a patient with metachronous lesions appearing at different times with similar radiological findings at different loci of the same hemisphere. Discrimination among multifocal and multicentric gliomas requires genetic workup because radiological and temporal findings may fail to allow adequate discrimination. |
format | Online Article Text |
id | pubmed-10165940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-101659402023-05-09 Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations Msheik, Ali Fares, Youssef Hamoud, Maarouf Atat, Rami Cureus Neurology Gliomas are among the most common primary tumors of the brain. Discrimination among tumors of more than one focus has segregated the latter into two groups: multifocal gliomas and multicentric gliomas (MCGs). In this case series, outcomes among three patients are described and discussed in light of the findings present in the literature. Ideally, it is crucial to consider genetic testing for categorizing each tumor. This can help determine the original genetic mutations of MCGs and allow to establish necessary screening testing for early detection. We present the cases of three patients diagnosed with cranial gliomas. The first case showed two synchronous gliomas at different loci in the right hemisphere. The second patient showed synchronous lesions on cranial magnetic resonance imaging in each hemisphere. The third case was of a patient with metachronous lesions appearing at different times with similar radiological findings at different loci of the same hemisphere. Discrimination among multifocal and multicentric gliomas requires genetic workup because radiological and temporal findings may fail to allow adequate discrimination. Cureus 2023-04-08 /pmc/articles/PMC10165940/ /pubmed/37168179 http://dx.doi.org/10.7759/cureus.37284 Text en Copyright © 2023, Msheik et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Neurology Msheik, Ali Fares, Youssef Hamoud, Maarouf Atat, Rami Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations |
title | Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations |
title_full | Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations |
title_fullStr | Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations |
title_full_unstemmed | Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations |
title_short | Unraveling the Complexity of Multicentric Gliomas: Insights Into Chronicity and Genetic Aberrations |
title_sort | unraveling the complexity of multicentric gliomas: insights into chronicity and genetic aberrations |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165940/ https://www.ncbi.nlm.nih.gov/pubmed/37168179 http://dx.doi.org/10.7759/cureus.37284 |
work_keys_str_mv | AT msheikali unravelingthecomplexityofmulticentricgliomasinsightsintochronicityandgeneticaberrations AT faresyoussef unravelingthecomplexityofmulticentricgliomasinsightsintochronicityandgeneticaberrations AT hamoudmaarouf unravelingthecomplexityofmulticentricgliomasinsightsintochronicityandgeneticaberrations AT atatrami unravelingthecomplexityofmulticentricgliomasinsightsintochronicityandgeneticaberrations |