EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

Neuronal activity causes use-dependent decline in protein function. However, it is unclear how this is coupled to local quality control mechanisms. We show in Drosophila that the endocytic protein Endophilin-A (EndoA) connects activity-induced calcium influx to synaptic autophagy and neuronal surviv...

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Detalles Bibliográficos
Autores principales: Bademosi, Adekunle T., Decet, Marianna, Kuenen, Sabine, Calatayud, Carles, Swerts, Jef, Gallego, Sandra F., Schoovaerts, Nils, Karamanou, Spyridoula, Louros, Nikolaos, Martin, Ella, Sibarita, Jean-Baptiste, Vints, Katlijn, Gounko, Natalia V., Meunier, Frédéric A., Economou, Anastassios, Versées, Wim, Rousseau, Frederic, Schymkowitz, Joost, Soukup, Sandra-F., Verstreken, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166451/
https://www.ncbi.nlm.nih.gov/pubmed/36827984
http://dx.doi.org/10.1016/j.neuron.2023.02.001

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