Secondary structure of the human mitochondrial genome affects formation of deletions

BACKGROUND: Aging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, but this alone does not fully explain their distribution. Here, we hypothesized...

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Detalles Bibliográficos
Autores principales: Shamanskiy, Victor, Mikhailova, Alina A., Tretiakov, Evgenii O., Ushakova, Kristina, Mikhailova, Alina G., Oreshkov, Sergei, Knorre, Dmitry A., Ree, Natalia, Overdevest, Jonathan B., Lukowski, Samuel W., Gostimskaya, Irina, Yurov, Valerian, Liou, Chia-Wei, Lin, Tsu-Kung, Kunz, Wolfram S., Reymond, Alexandre, Mazunin, Ilya, Bazykin, Georgii A., Fellay, Jacques, Tanaka, Masashi, Khrapko, Konstantin, Gunbin, Konstantin, Popadin, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166460/
https://www.ncbi.nlm.nih.gov/pubmed/37158879
http://dx.doi.org/10.1186/s12915-023-01606-1

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