GalNAc-T14 may Contribute to Production of Galactose-Deficient Immunoglobulin A1, the Main Autoantigen in IgA Nephropathy

INTRODUCTION: Immunoglobulin A1 (IgA1) with galactose-deficient O-glycans (Gd-IgA1) play a key role in the pathogenesis of IgA nephropathy (IgAN). Mucosal-tissue infections increase IL-6 production and, in patients with IgAN, are often associated with macroscopic hematuria. IgA1-secreting cell lines...

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Detalles Bibliográficos
Autores principales: Jemelkova, Jana, Stuchlova Horynova, Milada, Kosztyu, Petr, Zachova, Katerina, Zadrazil, Josef, Galuszkova, Dana, Takahashi, Kazuo, Novak, Jan, Raska, Milan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166743/
https://www.ncbi.nlm.nih.gov/pubmed/37180502
http://dx.doi.org/10.1016/j.ekir.2023.02.1072

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