Excitatory Dysfunction Drives Network and Calcium Handling Deficits in 16p11.2 Duplication Schizophrenia Induced Pluripotent Stem Cell–Derived Neurons

BACKGROUND: Schizophrenia (SCZ) is a debilitating psychiatric disorder with a large genetic contribution; however, its neurodevelopmental substrates remain largely unknown. Modeling pathogenic processes in SCZ using human induced pluripotent stem cell–derived neurons (iNs) has emerged as a promising...

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Detalles Bibliográficos
Autores principales: Parnell, Euan, Culotta, Lorenza, Forrest, Marc P., Jalloul, Hiba A., Eckman, Blair L., Loizzo, Daniel D., Horan, Katherine K.E., Santos, Marc Dos, Piguel, Nicolas H., Tai, Derek J.C., Zhang, Hanwen, Gertler, Tracy S., Simkin, Dina, Sanders, Alan R., Talkowski, Michael E., Gejman, Pablo V., Kiskinis, Evangelos, Duan, Jubao, Penzes, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166768/
https://www.ncbi.nlm.nih.gov/pubmed/36581494
http://dx.doi.org/10.1016/j.biopsych.2022.11.005

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