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Functional lung imaging using novel and emerging MRI techniques

Respiratory diseases are leading causes of death and disability in the world. While early diagnosis is key, this has proven difficult due to the lack of sensitive and non-invasive tools. Computed tomography is regarded as the gold standard for structural lung imaging but lacks functional information...

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Detalles Bibliográficos
Autores principales: Foo, Chuan T., Langton, David, Thompson, Bruce R., Thien, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166823/
https://www.ncbi.nlm.nih.gov/pubmed/37181360
http://dx.doi.org/10.3389/fmed.2023.1060940
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author Foo, Chuan T.
Langton, David
Thompson, Bruce R.
Thien, Francis
author_facet Foo, Chuan T.
Langton, David
Thompson, Bruce R.
Thien, Francis
author_sort Foo, Chuan T.
collection PubMed
description Respiratory diseases are leading causes of death and disability in the world. While early diagnosis is key, this has proven difficult due to the lack of sensitive and non-invasive tools. Computed tomography is regarded as the gold standard for structural lung imaging but lacks functional information and involves significant radiation exposure. Lung magnetic resonance imaging (MRI) has historically been challenging due to its short T2 and low proton density. Hyperpolarised gas MRI is an emerging technique that is able to overcome these difficulties, permitting the functional and microstructural evaluation of the lung. Other novel imaging techniques such as fluorinated gas MRI, oxygen-enhanced MRI, Fourier decomposition MRI and phase-resolved functional lung imaging can also be used to interrogate lung function though they are currently at varying stages of development. This article provides a clinically focused review of these contrast and non-contrast MR imaging techniques and their current applications in lung disease.
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spelling pubmed-101668232023-05-10 Functional lung imaging using novel and emerging MRI techniques Foo, Chuan T. Langton, David Thompson, Bruce R. Thien, Francis Front Med (Lausanne) Medicine Respiratory diseases are leading causes of death and disability in the world. While early diagnosis is key, this has proven difficult due to the lack of sensitive and non-invasive tools. Computed tomography is regarded as the gold standard for structural lung imaging but lacks functional information and involves significant radiation exposure. Lung magnetic resonance imaging (MRI) has historically been challenging due to its short T2 and low proton density. Hyperpolarised gas MRI is an emerging technique that is able to overcome these difficulties, permitting the functional and microstructural evaluation of the lung. Other novel imaging techniques such as fluorinated gas MRI, oxygen-enhanced MRI, Fourier decomposition MRI and phase-resolved functional lung imaging can also be used to interrogate lung function though they are currently at varying stages of development. This article provides a clinically focused review of these contrast and non-contrast MR imaging techniques and their current applications in lung disease. Frontiers Media S.A. 2023-04-25 /pmc/articles/PMC10166823/ /pubmed/37181360 http://dx.doi.org/10.3389/fmed.2023.1060940 Text en Copyright © 2023 Foo, Langton, Thompson and Thien. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Foo, Chuan T.
Langton, David
Thompson, Bruce R.
Thien, Francis
Functional lung imaging using novel and emerging MRI techniques
title Functional lung imaging using novel and emerging MRI techniques
title_full Functional lung imaging using novel and emerging MRI techniques
title_fullStr Functional lung imaging using novel and emerging MRI techniques
title_full_unstemmed Functional lung imaging using novel and emerging MRI techniques
title_short Functional lung imaging using novel and emerging MRI techniques
title_sort functional lung imaging using novel and emerging mri techniques
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166823/
https://www.ncbi.nlm.nih.gov/pubmed/37181360
http://dx.doi.org/10.3389/fmed.2023.1060940
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