Screening for DAX1/EWS‐FLI1 functional inhibitors identified dihydroorotate dehydrogenase as a therapeutic target for Ewing's sarcoma

OBJECTIVE: EWS‐FLI1 is the most common oncogenic fusion protein in Ewing's sarcoma family tumors (ESFTs). DAX1, an orphan member of the nuclear receptor superfamily, is up‐regulated by EWS‐FLI1 and plays a key role in the transformed phenotype of ESFTs. METHODS: To discover a functional inhibit...

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Detalles Bibliográficos
Autores principales: Watanabe, Miwa, Kosaka, Hiromichi, Sugawara, Masamori, Maemoto, Michihiro, Ono, Yoko, Uemori, Takeshi, Shizu, Ryota, Yoshinari, Kouichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166890/
https://www.ncbi.nlm.nih.gov/pubmed/36825574
http://dx.doi.org/10.1002/cam4.5741

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