Cargando…

TPX2 promotes ovarian tumorigenesis by interacting with Lamin A/C and affecting its stability

OBJECTIVE: Ovarian cancer (OC) is one of the fatal gynecologic malignancies. However, there are no effective prognostic or therapeutic indicators for OC. Herein, we aim to reveal the potential function of targeting protein for Xklp2 (TPX2) in OC progression. METHODS: Immunohistochemical and bioinfor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Xin, Cao, Jiazhen, Zheng, Hui, Ma, Xiaolu, Wang, Yanchun, Tong, Ying, Xie, Suhong, Lu, Renquan, Guo, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	RESEARCH ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166900/ https://www.ncbi.nlm.nih.gov/pubmed/36789877 http://dx.doi.org/10.1002/cam4.5683

Ejemplares similares

CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis
por: Wang, Fuqiang, et al.
Publicado: (2019)

IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis
por: Zheng, Hui, et al.
Publicado: (2023)

TTK is a potential therapeutic target for cisplatin-resistant ovarian cancer
por: Liu, Yixuan, et al.
Publicado: (2021)

Serology-Based Model for Personalized Epithelial Ovarian Cancer Risk Evaluation
por: Yan, Tianqing, et al.
Publicado: (2022)

Inhibition of MCM2 enhances the sensitivity of ovarian cancer cell to carboplatin
por: Deng, Minjie, et al.
Publicado: (2019)

Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin
por: Zhang, Jing, et al.
Publicado: (2021)

Enhanced Stability of Li-RHC Embedded in an Adaptive TPX™ Polymer Scaffold
por: Le, Thi Thu, et al.
Publicado: (2020)

Identification of the key genes associated with chemotherapy sensitivity in ovarian cancer patients
por: Zheng, Hui, et al.
Publicado: (2020)

Systematic comparison of TPX and TPX3 devices regarding luminosity measurements in the ATLAS cavern
por: Fiedler, Petr
Publicado: (2021)

MYSM1 induces apoptosis and sensitizes TNBC cells to cisplatin via RSK3–phospho-BAD pathway
por: Guan, Xiaolin, et al.
Publicado: (2022)

Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability
por: Hsu, Chao-Wen, et al.
Publicado: (2017)

GSG2 Promotes Development and Predicts Poor Prognosis of Ovarian Cancer
por: Huang, Yan, et al.
Publicado: (2021)

A Risk of Venous Thromboembolism Algorithm as a Predictor of Venous Thromboembolism in Patients with Colorectal Cancer
por: Chen, Ying, et al.
Publicado: (2021)

Differentially Expressed Genes in Clear Cell Renal Cell Carcinoma as a Potential Marker for Prognostic and Immune Signatures
por: Tong, Ying, et al.
Publicado: (2021)

Study TPX-100-5: intra-articular TPX-100 significantly delays pathological bone shape change and stabilizes cartilage in moderate to severe bilateral knee OA
por: McGuire, Dawn, et al.
Publicado: (2021)

TPX2 is a prognostic marker and promotes cell proliferation in neuroblastoma
por: Koike, Yuhki, et al.
Publicado: (2022)

Human leukocyte antigen-E alleles and expression in patients with serous ovarian cancer
por: Zheng, Hui, et al.
Publicado: (2015)

TPX2 joins 53BP1 to maintain DNA repair and fork stability
por: Cantor, Sharon
Publicado: (2019)

Targeting endoplasmic reticulum stress signaling in ovarian cancer therapy
por: Yan, Tianqing, et al.
Publicado: (2023)

MUS81 Participates in the Progression of Serous Ovarian Cancer Associated With Dysfunctional DNA Repair System
por: Lu, Renquan, et al.
Publicado: (2019)

Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons
por: Chen, Wen-Shin, et al.
Publicado: (2017)

AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation
por: Asteriti, Italia Anna, et al.
Publicado: (2023)

Transmission of Exosomal TPX2 Promotes Metastasis and Resistance of NSCLC Cells to Docetaxel
por: Hu, Jiaru, et al.
Publicado: (2023)

TPX2 is a drag on Eg5
por: Leslie, Mitch
Publicado: (2011)

TPX: Biomedical literature search made easy
por: Joseph, Thomas, et al.
Publicado: (2012)

RHPN1-AS1 promotes ovarian carcinogenesis by sponging miR-485-5p and releasing TPX2 mRNA
por: Cui, Shoubin, et al.
Publicado: (2021)

Adducin‐1 is essential for spindle pole integrity through its interaction with TPX2
por: Hsu, Wen‐Hsin, et al.
Publicado: (2018)

PTBP3 promotes tumorigenesis of glioblastoma by stabilizing Twist1
por: Xie, Peng, et al.
Publicado: (2022)

Structural insight into TPX2-stimulated microtubule assembly
por: Zhang, Rui, et al.
Publicado: (2017)

Prognostic significance of TPX2 and NIBP in esophageal cancer
por: Sui, Chao, et al.
Publicado: (2019)

Genome-wide analysis of the TPX2 family proteins in Eucalyptus grandis
por: Du, Pingzhou, et al.
Publicado: (2016)

TPX2 Promotes Metastasis and Serves as a Marker of Poor Prognosis in Non-Small Cell Lung Cancer
por: Zhou, Fang, et al.
Publicado: (2020)

TPX2 promotes glioma cell proliferation and invasion via activation of the AKT signaling pathway
por: Gu, Jian-Jun, et al.
Publicado: (2016)

HMGB3 is Associated With an Unfavorable Prognosis of Neuroblastoma and Promotes Tumor Progression by Mediating TPX2
por: Zhong, Xiaodan, et al.
Publicado: (2021)

Capable Infection of Hepatitis B Virus in Diffuse Large B-cell Lymphoma
por: Wang, Yanchun, et al.
Publicado: (2018)

TPX2 expression is associated with poor survival in gastric cancer
por: Tomii, Chiharu, et al.
Publicado: (2017)

Overexpression of TPX2 is associated with progression and prognosis of prostate cancer
por: Zou, Jun, et al.
Publicado: (2018)

Structural analysis of the role of TPX2 in branching microtubule nucleation
por: Alfaro-Aco, Raymundo, et al.
Publicado: (2017)

Therapeutic targeting of the TPX2/TTK network in colorectal cancer
por: Shaath, Hibah, et al.
Publicado: (2023)

Interaction of spindle assembly factor TPX2 with importins-α/β inhibits protein phase separation
por: Safari, Mohammad S., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4nribgg1qqlgb2slhlgklh6fpj