Cargando…

HBcAb positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma

BACKGROUND: Hepatitis B core antibody (HBcAb) positivity is considered a prior hepatitis B virus (HBV) infection. However, little is known about the effect of HBcAb positivity on surgical safety for hilar cholangiocarcinoma (hCCA). The present study aims to investigate the role of HBcAb positivity o...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Wen‐Qiang, Xu, Guang‐Yuan, Li, Jian, Liang, Bin‐Yong, Li, Jiang, Lin, Mei‐Long, Chen, Xiao‐Ping, Zhang, Er‐Lei, Huang, Zhi‐Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166974/
https://www.ncbi.nlm.nih.gov/pubmed/36847156
http://dx.doi.org/10.1002/cam4.5740
_version_ 1785038561311981568
author Wang, Wen‐Qiang
Xu, Guang‐Yuan
Li, Jian
Liang, Bin‐Yong
Li, Jiang
Lin, Mei‐Long
Chen, Xiao‐Ping
Zhang, Er‐Lei
Huang, Zhi‐Yong
author_facet Wang, Wen‐Qiang
Xu, Guang‐Yuan
Li, Jian
Liang, Bin‐Yong
Li, Jiang
Lin, Mei‐Long
Chen, Xiao‐Ping
Zhang, Er‐Lei
Huang, Zhi‐Yong
author_sort Wang, Wen‐Qiang
collection PubMed
description BACKGROUND: Hepatitis B core antibody (HBcAb) positivity is considered a prior hepatitis B virus (HBV) infection. However, little is known about the effect of HBcAb positivity on surgical safety for hilar cholangiocarcinoma (hCCA). The present study aims to investigate the role of HBcAb positivity on postoperative complications of hCCA. METHODS: A retrospective analysis was performed on the status of HBcAb positivity, liver fibrosis, perioperative surgical complications, and long‐term outcomes of hCCA patients with Hepatitis B surface antigen (HBsAg) negativity who underwent surgical treatment in Tongji Hospital from April 2012 to September 2019. RESULTS: HBcAb positivity with negative HBsAg occurs in 137 hCCA patients (63.1%). A total of 99 hCCA patients with negative HBsAg underwent extended hemihepatectomy, of whom 69 (69.7%) and 30 (30.3%) were HBcAb‐positive and HBcAb‐negative, respectively. Significant fibrosis was detected in 63.8% of the patients with HBcAb‐positive, which was markedly higher than those with HBcAb‐negative (36.7%) (p = 0.016). The postoperative complications and 90‐day mortality rates were 37.4% (37/99) and 8.1% (8/99), respectively. The incidence of postoperative complications in HBcAb‐positive patients (44.9%) was significantly higher than that in HBcAb‐negative patients (20.0%) (p = 0.018). All the patients who died within 30‐day after surgery were HBcAb‐positive. Multivariate analysis showed that the independent risk factors for complications were HBcAb positivity, preoperative cholangitis, portal occlusion >15 min, and significant fibrosis. There were no significant differences in recurrence‐free survival (RFS) and overall survival (OS) between HBcAb‐positive and HBcAb‐negative patients (p = 0.642 and p = 0.400, respectively). CONCLUSIONS: HBcAb positivity is a common phenomenon in hCCA patients from China, a country with highly prevalent HBcAb positivity. The status of HBcAb‐positive markedly increases the incidence of postoperative complications after extended hemihepatectomy for hCCA patients.
format Online
Article
Text
id pubmed-10166974
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-101669742023-05-10 HBcAb positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma Wang, Wen‐Qiang Xu, Guang‐Yuan Li, Jian Liang, Bin‐Yong Li, Jiang Lin, Mei‐Long Chen, Xiao‐Ping Zhang, Er‐Lei Huang, Zhi‐Yong Cancer Med RESEARCH ARTICLES BACKGROUND: Hepatitis B core antibody (HBcAb) positivity is considered a prior hepatitis B virus (HBV) infection. However, little is known about the effect of HBcAb positivity on surgical safety for hilar cholangiocarcinoma (hCCA). The present study aims to investigate the role of HBcAb positivity on postoperative complications of hCCA. METHODS: A retrospective analysis was performed on the status of HBcAb positivity, liver fibrosis, perioperative surgical complications, and long‐term outcomes of hCCA patients with Hepatitis B surface antigen (HBsAg) negativity who underwent surgical treatment in Tongji Hospital from April 2012 to September 2019. RESULTS: HBcAb positivity with negative HBsAg occurs in 137 hCCA patients (63.1%). A total of 99 hCCA patients with negative HBsAg underwent extended hemihepatectomy, of whom 69 (69.7%) and 30 (30.3%) were HBcAb‐positive and HBcAb‐negative, respectively. Significant fibrosis was detected in 63.8% of the patients with HBcAb‐positive, which was markedly higher than those with HBcAb‐negative (36.7%) (p = 0.016). The postoperative complications and 90‐day mortality rates were 37.4% (37/99) and 8.1% (8/99), respectively. The incidence of postoperative complications in HBcAb‐positive patients (44.9%) was significantly higher than that in HBcAb‐negative patients (20.0%) (p = 0.018). All the patients who died within 30‐day after surgery were HBcAb‐positive. Multivariate analysis showed that the independent risk factors for complications were HBcAb positivity, preoperative cholangitis, portal occlusion >15 min, and significant fibrosis. There were no significant differences in recurrence‐free survival (RFS) and overall survival (OS) between HBcAb‐positive and HBcAb‐negative patients (p = 0.642 and p = 0.400, respectively). CONCLUSIONS: HBcAb positivity is a common phenomenon in hCCA patients from China, a country with highly prevalent HBcAb positivity. The status of HBcAb‐positive markedly increases the incidence of postoperative complications after extended hemihepatectomy for hCCA patients. John Wiley and Sons Inc. 2023-02-27 /pmc/articles/PMC10166974/ /pubmed/36847156 http://dx.doi.org/10.1002/cam4.5740 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Wang, Wen‐Qiang
Xu, Guang‐Yuan
Li, Jian
Liang, Bin‐Yong
Li, Jiang
Lin, Mei‐Long
Chen, Xiao‐Ping
Zhang, Er‐Lei
Huang, Zhi‐Yong
HBcAb positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma
title HBcAb positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma
title_full HBcAb positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma
title_fullStr HBcAb positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma
title_full_unstemmed HBcAb positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma
title_short HBcAb positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma
title_sort hbcab positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166974/
https://www.ncbi.nlm.nih.gov/pubmed/36847156
http://dx.doi.org/10.1002/cam4.5740
work_keys_str_mv AT wangwenqiang hbcabpositivityincreasestheriskofpostoperativecomplicationsafterextendedhemihepatectomyforhilarcholangiocarcinoma
AT xuguangyuan hbcabpositivityincreasestheriskofpostoperativecomplicationsafterextendedhemihepatectomyforhilarcholangiocarcinoma
AT lijian hbcabpositivityincreasestheriskofpostoperativecomplicationsafterextendedhemihepatectomyforhilarcholangiocarcinoma
AT liangbinyong hbcabpositivityincreasestheriskofpostoperativecomplicationsafterextendedhemihepatectomyforhilarcholangiocarcinoma
AT lijiang hbcabpositivityincreasestheriskofpostoperativecomplicationsafterextendedhemihepatectomyforhilarcholangiocarcinoma
AT linmeilong hbcabpositivityincreasestheriskofpostoperativecomplicationsafterextendedhemihepatectomyforhilarcholangiocarcinoma
AT chenxiaoping hbcabpositivityincreasestheriskofpostoperativecomplicationsafterextendedhemihepatectomyforhilarcholangiocarcinoma
AT zhangerlei hbcabpositivityincreasestheriskofpostoperativecomplicationsafterextendedhemihepatectomyforhilarcholangiocarcinoma
AT huangzhiyong hbcabpositivityincreasestheriskofpostoperativecomplicationsafterextendedhemihepatectomyforhilarcholangiocarcinoma