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Imaging features of the PI-RADS for predicting extraprostatic extension of prostate cancer: systematic review and meta-analysis

OBJECTIVES: To systematically determine the diagnostic performance of each MRI feature of the PI-RADS for predicting extraprostatic extension (EPE) in prostate cancer. METHODS: A literature search in the MEDLINE and EMBASE databases was conducted to identify original studies reporting the accuracy o...

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Autores principales: Choi, Moon Hyung, Kim, Dong Hwan, Lee, Young Joon, Rha, Sung Eun, Lee, Ji Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167060/
https://www.ncbi.nlm.nih.gov/pubmed/37156971
http://dx.doi.org/10.1186/s13244-023-01422-9
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author Choi, Moon Hyung
Kim, Dong Hwan
Lee, Young Joon
Rha, Sung Eun
Lee, Ji Youl
author_facet Choi, Moon Hyung
Kim, Dong Hwan
Lee, Young Joon
Rha, Sung Eun
Lee, Ji Youl
author_sort Choi, Moon Hyung
collection PubMed
description OBJECTIVES: To systematically determine the diagnostic performance of each MRI feature of the PI-RADS for predicting extraprostatic extension (EPE) in prostate cancer. METHODS: A literature search in the MEDLINE and EMBASE databases was conducted to identify original studies reporting the accuracy of each feature on MRI for the dichotomous diagnosis of EPE. The meta-analytic pooled diagnostic odds ratio (DOR), sensitivity, specificity, and their 95% confidence intervals (CIs) were obtained using a bivariate random-effects model. RESULTS: After screening 1955 studies, 17 studies with a total of 3062 men were included. All six imaging features, i.e., bulging prostatic contour, irregular or spiculated margin, asymmetry or invasion of neurovascular bundle, obliteration of rectoprostatic angle, tumor-capsule interface > 10 mm, and breach of the capsule with evidence of direct tumor extension, were significantly associated with EPE. Breach of the capsule with direct tumor extension demonstrated the highest pooled DOR (15.6, 95% CI [7.7–31.5]) followed by tumor-capsule interface > 10 mm (10.5 [5.4–20.2]), asymmetry or invasion of neurovascular bundle (7.6 [3.8–15.2]), and obliteration of rectoprostatic angle (6.1 [3.8–9.8]). Irregular or spiculated margin showed the lowest pooled DOR (2.3 [1.3–4.2]). Breach of the capsule with direct tumor extension and tumor-capsule interface > 10 mm showed the highest pooled specificity (98.0% [96.2–99.0]) and sensitivity (86.3% [70.0–94.4]), respectively. CONCLUSIONS: Among the six MRI features of prostate cancer, breach of the capsule with direct tumor extension and tumor-capsule interface > 10 mm were the most predictive of EPE with the highest specificity and sensitivity, respectively. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13244-023-01422-9.
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spelling pubmed-101670602023-05-10 Imaging features of the PI-RADS for predicting extraprostatic extension of prostate cancer: systematic review and meta-analysis Choi, Moon Hyung Kim, Dong Hwan Lee, Young Joon Rha, Sung Eun Lee, Ji Youl Insights Imaging Original Article OBJECTIVES: To systematically determine the diagnostic performance of each MRI feature of the PI-RADS for predicting extraprostatic extension (EPE) in prostate cancer. METHODS: A literature search in the MEDLINE and EMBASE databases was conducted to identify original studies reporting the accuracy of each feature on MRI for the dichotomous diagnosis of EPE. The meta-analytic pooled diagnostic odds ratio (DOR), sensitivity, specificity, and their 95% confidence intervals (CIs) were obtained using a bivariate random-effects model. RESULTS: After screening 1955 studies, 17 studies with a total of 3062 men were included. All six imaging features, i.e., bulging prostatic contour, irregular or spiculated margin, asymmetry or invasion of neurovascular bundle, obliteration of rectoprostatic angle, tumor-capsule interface > 10 mm, and breach of the capsule with evidence of direct tumor extension, were significantly associated with EPE. Breach of the capsule with direct tumor extension demonstrated the highest pooled DOR (15.6, 95% CI [7.7–31.5]) followed by tumor-capsule interface > 10 mm (10.5 [5.4–20.2]), asymmetry or invasion of neurovascular bundle (7.6 [3.8–15.2]), and obliteration of rectoprostatic angle (6.1 [3.8–9.8]). Irregular or spiculated margin showed the lowest pooled DOR (2.3 [1.3–4.2]). Breach of the capsule with direct tumor extension and tumor-capsule interface > 10 mm showed the highest pooled specificity (98.0% [96.2–99.0]) and sensitivity (86.3% [70.0–94.4]), respectively. CONCLUSIONS: Among the six MRI features of prostate cancer, breach of the capsule with direct tumor extension and tumor-capsule interface > 10 mm were the most predictive of EPE with the highest specificity and sensitivity, respectively. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13244-023-01422-9. Springer Vienna 2023-05-08 /pmc/articles/PMC10167060/ /pubmed/37156971 http://dx.doi.org/10.1186/s13244-023-01422-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Choi, Moon Hyung
Kim, Dong Hwan
Lee, Young Joon
Rha, Sung Eun
Lee, Ji Youl
Imaging features of the PI-RADS for predicting extraprostatic extension of prostate cancer: systematic review and meta-analysis
title Imaging features of the PI-RADS for predicting extraprostatic extension of prostate cancer: systematic review and meta-analysis
title_full Imaging features of the PI-RADS for predicting extraprostatic extension of prostate cancer: systematic review and meta-analysis
title_fullStr Imaging features of the PI-RADS for predicting extraprostatic extension of prostate cancer: systematic review and meta-analysis
title_full_unstemmed Imaging features of the PI-RADS for predicting extraprostatic extension of prostate cancer: systematic review and meta-analysis
title_short Imaging features of the PI-RADS for predicting extraprostatic extension of prostate cancer: systematic review and meta-analysis
title_sort imaging features of the pi-rads for predicting extraprostatic extension of prostate cancer: systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167060/
https://www.ncbi.nlm.nih.gov/pubmed/37156971
http://dx.doi.org/10.1186/s13244-023-01422-9
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