Inhibition of CXorf56 promotes PARP inhibitor-induced cytotoxicity in triple-negative breast cancer

Poly(ADP-ribose) polymerase inhibitors (PARPis) induce DNA lesions that preferentially kill homologous recombination (HR)-deficient breast cancers induced by BRCA mutations, which exhibit a low incidence in breast cancer, thereby limiting the benefits of PARPis. Additionally, breast cancer cells, pa...

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Detalles Bibliográficos
Autores principales: Zhu, Ying, Liu, Zhixian, Gui, Liang, Yun, Wen, Mao, Changfei, Deng, Rong, Yao, Yufeng, Yu, Qiao, Feng, Jifeng, Ma, Hongxia, Bao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167262/
https://www.ncbi.nlm.nih.gov/pubmed/37156759
http://dx.doi.org/10.1038/s41523-023-00540-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167262/
https://www.ncbi.nlm.nih.gov/pubmed/37156759
http://dx.doi.org/10.1038/s41523-023-00540-3

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