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Decreased RNA polymerase III subunit expression leads to defects in oligodendrocyte development

INTRODUCTION: RNA polymerase III (Pol III) is a critical enzymatic complex tasked with the transcription of ubiquitous non-coding RNAs including 5S rRNA and all tRNA genes. Despite the constitutive nature of this enzyme, hypomorphic biallelic pathogenic variants in genes encoding subunits of Pol III...

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Detalles Bibliográficos
Autores principales:	Macintosh, Julia, Michell-Robinson, Mackenzie, Chen, Xiaoru, Bernard, Geneviève
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167296/ https://www.ncbi.nlm.nih.gov/pubmed/37179550 http://dx.doi.org/10.3389/fnins.2023.1167047

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