Cargando…

Effect of the categorization method on the diagnostic performance of ultrasound risk stratification systems for thyroid nodules

OBJECTIVE: To evaluate whether the categorization methods of risk stratification systems (RSSs) is a decisive factor that influenced the diagnostic performances and unnecessary FNA rates in order to choose optimal RSS for the management of thyroid nodules. METHODS: From July 2013 to January 2019, 26...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Chao, Cui, Yiyang, Li, Jing, Yu, Jing, Wang, Yan, Si, Caifeng, Cui, Kefei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167303/
https://www.ncbi.nlm.nih.gov/pubmed/37182157
http://dx.doi.org/10.3389/fonc.2023.1073891
_version_ 1785038635030020096
author Fu, Chao
Cui, Yiyang
Li, Jing
Yu, Jing
Wang, Yan
Si, Caifeng
Cui, Kefei
author_facet Fu, Chao
Cui, Yiyang
Li, Jing
Yu, Jing
Wang, Yan
Si, Caifeng
Cui, Kefei
author_sort Fu, Chao
collection PubMed
description OBJECTIVE: To evaluate whether the categorization methods of risk stratification systems (RSSs) is a decisive factor that influenced the diagnostic performances and unnecessary FNA rates in order to choose optimal RSS for the management of thyroid nodules. METHODS: From July 2013 to January 2019, 2667 patients with 3944 thyroid nodules had undergone pathological diagnosis after thyroidectomy and/or US-guided FNA. US categories were assigned according to the six RSSs. The diagnostic performances and unnecessary FNA rates were calculated and compared according to the US-based final assessment categories and the unified size thresholds for biopsy proposed by ACR-TIRADS, respectively. RESULTS: A total of 1781 (45.2%) thyroid nodules were diagnosed as malignant after thyroidectomy or biopsy. Significantly lowest specificity and accuracy, along with the highest unnecessary FNA rates were seen in EU-TIRADS for both US categories (47.9%, 70.2%, and 39.4%, respectively, all P < 0.05) and indications for FNA (54.2%, 50.0%, and 55.4%, respectively, all P < 0.05). Diagnostic performances for US-based final assessment categories exhibited similar accuracy for AI-TIRADS, Kwak-TIRADS, C-TIRADS, and ATA guidelines (78.0%, 77.8%, 77.9%, and 76.3%, respectively, all P > 0.05), while the lowest unnecessary FNA rate was seen in C-TIRADS (30.9%) and without significant differences to that of AI-TIRADS, Kwak-TIRADS, and ATA guideline (31.5%, 31.7%, and 33.6%, respectively, all P > 0.05). Diagnostic performance for US-FNA indications showed similar accuracy for ACR-TIRADS, Kwak-TIRADS, C-TIRADS and ATA guidelines (58.0%, 59.7%, 58.7%, and 57.1%, respectively, all P > 0.05). The highest accuracy and lowest unnecessary FNA rate were seen in AI-TIRADS (61.9%, 38.6%) and without significant differences to that of Kwak-TIRADS(59.7%, 42.9%) and C-TIRADS 58.7%, 43.9%, all P > 0.05). CONCLUSION: The different US categorization methods used by each RSS were not determinant influential factors in diagnostic performance and unnecessary FNA rate. For daily clinical practice, the score-based counting RSS was an optimal choice.
format Online
Article
Text
id pubmed-10167303
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-101673032023-05-10 Effect of the categorization method on the diagnostic performance of ultrasound risk stratification systems for thyroid nodules Fu, Chao Cui, Yiyang Li, Jing Yu, Jing Wang, Yan Si, Caifeng Cui, Kefei Front Oncol Oncology OBJECTIVE: To evaluate whether the categorization methods of risk stratification systems (RSSs) is a decisive factor that influenced the diagnostic performances and unnecessary FNA rates in order to choose optimal RSS for the management of thyroid nodules. METHODS: From July 2013 to January 2019, 2667 patients with 3944 thyroid nodules had undergone pathological diagnosis after thyroidectomy and/or US-guided FNA. US categories were assigned according to the six RSSs. The diagnostic performances and unnecessary FNA rates were calculated and compared according to the US-based final assessment categories and the unified size thresholds for biopsy proposed by ACR-TIRADS, respectively. RESULTS: A total of 1781 (45.2%) thyroid nodules were diagnosed as malignant after thyroidectomy or biopsy. Significantly lowest specificity and accuracy, along with the highest unnecessary FNA rates were seen in EU-TIRADS for both US categories (47.9%, 70.2%, and 39.4%, respectively, all P < 0.05) and indications for FNA (54.2%, 50.0%, and 55.4%, respectively, all P < 0.05). Diagnostic performances for US-based final assessment categories exhibited similar accuracy for AI-TIRADS, Kwak-TIRADS, C-TIRADS, and ATA guidelines (78.0%, 77.8%, 77.9%, and 76.3%, respectively, all P > 0.05), while the lowest unnecessary FNA rate was seen in C-TIRADS (30.9%) and without significant differences to that of AI-TIRADS, Kwak-TIRADS, and ATA guideline (31.5%, 31.7%, and 33.6%, respectively, all P > 0.05). Diagnostic performance for US-FNA indications showed similar accuracy for ACR-TIRADS, Kwak-TIRADS, C-TIRADS and ATA guidelines (58.0%, 59.7%, 58.7%, and 57.1%, respectively, all P > 0.05). The highest accuracy and lowest unnecessary FNA rate were seen in AI-TIRADS (61.9%, 38.6%) and without significant differences to that of Kwak-TIRADS(59.7%, 42.9%) and C-TIRADS 58.7%, 43.9%, all P > 0.05). CONCLUSION: The different US categorization methods used by each RSS were not determinant influential factors in diagnostic performance and unnecessary FNA rate. For daily clinical practice, the score-based counting RSS was an optimal choice. Frontiers Media S.A. 2023-04-25 /pmc/articles/PMC10167303/ /pubmed/37182157 http://dx.doi.org/10.3389/fonc.2023.1073891 Text en Copyright © 2023 Fu, Cui, Li, Yu, Wang, Si and Cui https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Fu, Chao
Cui, Yiyang
Li, Jing
Yu, Jing
Wang, Yan
Si, Caifeng
Cui, Kefei
Effect of the categorization method on the diagnostic performance of ultrasound risk stratification systems for thyroid nodules
title Effect of the categorization method on the diagnostic performance of ultrasound risk stratification systems for thyroid nodules
title_full Effect of the categorization method on the diagnostic performance of ultrasound risk stratification systems for thyroid nodules
title_fullStr Effect of the categorization method on the diagnostic performance of ultrasound risk stratification systems for thyroid nodules
title_full_unstemmed Effect of the categorization method on the diagnostic performance of ultrasound risk stratification systems for thyroid nodules
title_short Effect of the categorization method on the diagnostic performance of ultrasound risk stratification systems for thyroid nodules
title_sort effect of the categorization method on the diagnostic performance of ultrasound risk stratification systems for thyroid nodules
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167303/
https://www.ncbi.nlm.nih.gov/pubmed/37182157
http://dx.doi.org/10.3389/fonc.2023.1073891
work_keys_str_mv AT fuchao effectofthecategorizationmethodonthediagnosticperformanceofultrasoundriskstratificationsystemsforthyroidnodules
AT cuiyiyang effectofthecategorizationmethodonthediagnosticperformanceofultrasoundriskstratificationsystemsforthyroidnodules
AT lijing effectofthecategorizationmethodonthediagnosticperformanceofultrasoundriskstratificationsystemsforthyroidnodules
AT yujing effectofthecategorizationmethodonthediagnosticperformanceofultrasoundriskstratificationsystemsforthyroidnodules
AT wangyan effectofthecategorizationmethodonthediagnosticperformanceofultrasoundriskstratificationsystemsforthyroidnodules
AT sicaifeng effectofthecategorizationmethodonthediagnosticperformanceofultrasoundriskstratificationsystemsforthyroidnodules
AT cuikefei effectofthecategorizationmethodonthediagnosticperformanceofultrasoundriskstratificationsystemsforthyroidnodules