Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis

Hepatocellular carcinoma (HCC) is the 3(rd) most deadly malignancy. Activated hepatic stellate cells (aHSC) give rise to cancer-associated fibroblasts in HCC and are considered a potential therapeutic target. Here we report that selective ablation of stearoyl CoA desaturase-2 (Scd2) in aHSC globally...

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Detalles Bibliográficos
Autores principales: Sinha, Sonal, Aizawa, Satoka, Nakano, Yasuhiro, Rialdi, Alexander, Choi, Hye Yeon, Shrestha, Rajan, Pan, Stephanie Q., Chen, Yibu, Li, Meng, Kapelanski-Lamoureux, Audrey, Yochum, Gregory, Sher, Linda, Monga, Satdarshan Paul, Lazaris, Anthoula, Machida, Keigo, Karin, Michael, Guccione, Ernesto, Tsukamoto, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167314/
https://www.ncbi.nlm.nih.gov/pubmed/37156770
http://dx.doi.org/10.1038/s41467-023-38406-8

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