SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion

Human sterile α motif and HD domain-containing protein 1 (SAMHD1) has deoxyribonucleoside triphosphohydrolase (dNTPase) activity that allows it to defend against human immunodeficiency virus type I (HIV-1) infections and regulate the cell cycle. Although SAMHD1 mutations have been identified in vari...

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Detalles Bibliográficos
Autores principales: An, Sunho, Vo, Tam Thuy Lu, Son, Taekwon, Choi, Hoon, Kim, Jinyoung, Lee, Juyeon, Kim, Byung Hoon, Choe, Misun, Ha, Eunyoung, Surh, Young-Joon, Kim, Kyu-Won, Seo, Ji Hae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167369/
https://www.ncbi.nlm.nih.gov/pubmed/37009792
http://dx.doi.org/10.1038/s12276-023-00961-x

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