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Transmission dynamics of a novel HIV/AIDS model through a higher-order Galerkin time discretization scheme

There are numerous contagious diseases caused by pathogenic microorganisms, including bacteria, viruses, fungi, and parasites, that have the propensity to culminate in fatal consequences. A communicable disease is an illness caused by a contagion agent or its toxins and spread directly or indirectly...

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Autores principales: Attaullah, Zeb, Kamil, Khan, Ilyas, Ahmad, Riaz, Eldin, Sayed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167370/
https://www.ncbi.nlm.nih.gov/pubmed/37156899
http://dx.doi.org/10.1038/s41598-023-34696-6
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author Attaullah
Zeb, Kamil
Khan, Ilyas
Ahmad, Riaz
Eldin, Sayed M.
author_facet Attaullah
Zeb, Kamil
Khan, Ilyas
Ahmad, Riaz
Eldin, Sayed M.
author_sort Attaullah
collection PubMed
description There are numerous contagious diseases caused by pathogenic microorganisms, including bacteria, viruses, fungi, and parasites, that have the propensity to culminate in fatal consequences. A communicable disease is an illness caused by a contagion agent or its toxins and spread directly or indirectly to a susceptible animal or human host by an infected person, animal, vector, or immaterial environment. Human immunodeficiency virus (HIV) infection, hepatitis A, B, and C, and measles are all examples of communicable diseases. Acquired immunodeficiency syndrome (AIDS) is a communicable disease caused by HIV infection that has become the most severe issue facing humanity. The research work in this paper is to numerically explore a mathematical model and demonstrate the dynamics of HIV/AIDS disease transmission using a continuous Galerkin–Petrov time discretization of a higher-order scheme, specifically the cGP(2)-scheme. Depict a graphical and tabular comparison between the outcomes of the mentioned scheme and those obtained through other classical schemes that exist in the literature. Further, a comparison is performed relative to the well-known fourth-order Ruge–Kutta (RK4) method with different step sizes. By contrast, the suggested approach provided more accurate results with a larger step size than RK4 with a smaller step size. After validation and confirmation of the suggested scheme and code, we implement the method to the extended model by introducing a treatment rate and show the impact of various non-linear source terms for the generation of new cells. We also determined the basic reproduction number and use the Routh-Hurwitz criterion to assess the stability of disease-free and unique endemic equilibrium states of the HIV model.
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spelling pubmed-101673702023-05-10 Transmission dynamics of a novel HIV/AIDS model through a higher-order Galerkin time discretization scheme Attaullah Zeb, Kamil Khan, Ilyas Ahmad, Riaz Eldin, Sayed M. Sci Rep Article There are numerous contagious diseases caused by pathogenic microorganisms, including bacteria, viruses, fungi, and parasites, that have the propensity to culminate in fatal consequences. A communicable disease is an illness caused by a contagion agent or its toxins and spread directly or indirectly to a susceptible animal or human host by an infected person, animal, vector, or immaterial environment. Human immunodeficiency virus (HIV) infection, hepatitis A, B, and C, and measles are all examples of communicable diseases. Acquired immunodeficiency syndrome (AIDS) is a communicable disease caused by HIV infection that has become the most severe issue facing humanity. The research work in this paper is to numerically explore a mathematical model and demonstrate the dynamics of HIV/AIDS disease transmission using a continuous Galerkin–Petrov time discretization of a higher-order scheme, specifically the cGP(2)-scheme. Depict a graphical and tabular comparison between the outcomes of the mentioned scheme and those obtained through other classical schemes that exist in the literature. Further, a comparison is performed relative to the well-known fourth-order Ruge–Kutta (RK4) method with different step sizes. By contrast, the suggested approach provided more accurate results with a larger step size than RK4 with a smaller step size. After validation and confirmation of the suggested scheme and code, we implement the method to the extended model by introducing a treatment rate and show the impact of various non-linear source terms for the generation of new cells. We also determined the basic reproduction number and use the Routh-Hurwitz criterion to assess the stability of disease-free and unique endemic equilibrium states of the HIV model. Nature Publishing Group UK 2023-05-08 /pmc/articles/PMC10167370/ /pubmed/37156899 http://dx.doi.org/10.1038/s41598-023-34696-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Attaullah
Zeb, Kamil
Khan, Ilyas
Ahmad, Riaz
Eldin, Sayed M.
Transmission dynamics of a novel HIV/AIDS model through a higher-order Galerkin time discretization scheme
title Transmission dynamics of a novel HIV/AIDS model through a higher-order Galerkin time discretization scheme
title_full Transmission dynamics of a novel HIV/AIDS model through a higher-order Galerkin time discretization scheme
title_fullStr Transmission dynamics of a novel HIV/AIDS model through a higher-order Galerkin time discretization scheme
title_full_unstemmed Transmission dynamics of a novel HIV/AIDS model through a higher-order Galerkin time discretization scheme
title_short Transmission dynamics of a novel HIV/AIDS model through a higher-order Galerkin time discretization scheme
title_sort transmission dynamics of a novel hiv/aids model through a higher-order galerkin time discretization scheme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167370/
https://www.ncbi.nlm.nih.gov/pubmed/37156899
http://dx.doi.org/10.1038/s41598-023-34696-6
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