Cargando…
Application of amide proton transfer imaging to pretreatment risk stratification of childhood neuroblastoma: comparison with neuron-specific enolase
BACKGROUND: The diagnosis and treatment of childhood neuroblastoma (NB) varies with different risk groups, thus requiring accurate preoperative risk assessment. This study aimed to verify the feasibility of amide proton transfer (APT) imaging in risk stratification of abdominal NB in children, and c...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167440/ https://www.ncbi.nlm.nih.gov/pubmed/37179906 http://dx.doi.org/10.21037/qims-22-780 |
_version_ | 1785038677427093504 |
---|---|
author | Jia, Xuan Wang, Wenqi Liang, Jiawei Ma, Xiaohui Chen, Weibo Wu, Dan Zhang, Hongxi Ni, Shaoqing Wu, Jiheng Lai, Can Zhang, Yi |
author_facet | Jia, Xuan Wang, Wenqi Liang, Jiawei Ma, Xiaohui Chen, Weibo Wu, Dan Zhang, Hongxi Ni, Shaoqing Wu, Jiheng Lai, Can Zhang, Yi |
author_sort | Jia, Xuan |
collection | PubMed |
description | BACKGROUND: The diagnosis and treatment of childhood neuroblastoma (NB) varies with different risk groups, thus requiring accurate preoperative risk assessment. This study aimed to verify the feasibility of amide proton transfer (APT) imaging in risk stratification of abdominal NB in children, and compare it with the serum neuron-specific enolase (NSE). METHODS: This prospective study enrolled 86 consecutive pediatric volunteers with suspected NB, and all subjects underwent abdominal APT imaging on a 3T magnetic resonance imaging scanner. A 4-pool Lorentzian fitting model was used to mitigate motion artifacts and separate the APT signal from the contaminating ones. The APT values were measured from tumor regions delineated by two experienced radiologists. The one-way analysis of variance, independent-sample t-test, Mann-Whitney U-test, and receiver operating characteristic analysis were performed to evaluate and compare the risk stratification performance of the APT value and serum NSE index—a routine biomarker of NB in clinics. RESULTS: Thirty-four cases (mean age, 38.6±32.4 months; 5 very-low-risk, 5 low-risk, 8 intermediate-risk and 16 high-risk ones) were included in the final analysis. The APT values were significantly higher in high-risk NB (5.80%±1.27%) than in the non-high-risk group (3.88%±1.01%) composed of the other three risk groups (P<0.001). However, there was no significant difference (P=0.18) in NSE levels between the high-risk (93.05±97.14 ng/mL) and non-high-risk groups (41.45±30.99 ng/mL). The associated area under the curve (AUC) of the APT parameter (AUC =0.89) in differentiating high-risk NB from non-high-risk NB was significantly higher (P=0.03) than that of NSE (AUC =0.64). CONCLUSIONS: As an emerging non-invasive magnetic resonance imaging technique, APT imaging has a promising prospect for distinguishing high-risk NB from non-high-risk NB in routine clinical applications. |
format | Online Article Text |
id | pubmed-10167440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-101674402023-05-10 Application of amide proton transfer imaging to pretreatment risk stratification of childhood neuroblastoma: comparison with neuron-specific enolase Jia, Xuan Wang, Wenqi Liang, Jiawei Ma, Xiaohui Chen, Weibo Wu, Dan Zhang, Hongxi Ni, Shaoqing Wu, Jiheng Lai, Can Zhang, Yi Quant Imaging Med Surg Original Article BACKGROUND: The diagnosis and treatment of childhood neuroblastoma (NB) varies with different risk groups, thus requiring accurate preoperative risk assessment. This study aimed to verify the feasibility of amide proton transfer (APT) imaging in risk stratification of abdominal NB in children, and compare it with the serum neuron-specific enolase (NSE). METHODS: This prospective study enrolled 86 consecutive pediatric volunteers with suspected NB, and all subjects underwent abdominal APT imaging on a 3T magnetic resonance imaging scanner. A 4-pool Lorentzian fitting model was used to mitigate motion artifacts and separate the APT signal from the contaminating ones. The APT values were measured from tumor regions delineated by two experienced radiologists. The one-way analysis of variance, independent-sample t-test, Mann-Whitney U-test, and receiver operating characteristic analysis were performed to evaluate and compare the risk stratification performance of the APT value and serum NSE index—a routine biomarker of NB in clinics. RESULTS: Thirty-four cases (mean age, 38.6±32.4 months; 5 very-low-risk, 5 low-risk, 8 intermediate-risk and 16 high-risk ones) were included in the final analysis. The APT values were significantly higher in high-risk NB (5.80%±1.27%) than in the non-high-risk group (3.88%±1.01%) composed of the other three risk groups (P<0.001). However, there was no significant difference (P=0.18) in NSE levels between the high-risk (93.05±97.14 ng/mL) and non-high-risk groups (41.45±30.99 ng/mL). The associated area under the curve (AUC) of the APT parameter (AUC =0.89) in differentiating high-risk NB from non-high-risk NB was significantly higher (P=0.03) than that of NSE (AUC =0.64). CONCLUSIONS: As an emerging non-invasive magnetic resonance imaging technique, APT imaging has a promising prospect for distinguishing high-risk NB from non-high-risk NB in routine clinical applications. AME Publishing Company 2023-03-13 2023-05-01 /pmc/articles/PMC10167440/ /pubmed/37179906 http://dx.doi.org/10.21037/qims-22-780 Text en 2023 Quantitative Imaging in Medicine and Surgery. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Jia, Xuan Wang, Wenqi Liang, Jiawei Ma, Xiaohui Chen, Weibo Wu, Dan Zhang, Hongxi Ni, Shaoqing Wu, Jiheng Lai, Can Zhang, Yi Application of amide proton transfer imaging to pretreatment risk stratification of childhood neuroblastoma: comparison with neuron-specific enolase |
title | Application of amide proton transfer imaging to pretreatment risk stratification of childhood neuroblastoma: comparison with neuron-specific enolase |
title_full | Application of amide proton transfer imaging to pretreatment risk stratification of childhood neuroblastoma: comparison with neuron-specific enolase |
title_fullStr | Application of amide proton transfer imaging to pretreatment risk stratification of childhood neuroblastoma: comparison with neuron-specific enolase |
title_full_unstemmed | Application of amide proton transfer imaging to pretreatment risk stratification of childhood neuroblastoma: comparison with neuron-specific enolase |
title_short | Application of amide proton transfer imaging to pretreatment risk stratification of childhood neuroblastoma: comparison with neuron-specific enolase |
title_sort | application of amide proton transfer imaging to pretreatment risk stratification of childhood neuroblastoma: comparison with neuron-specific enolase |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167440/ https://www.ncbi.nlm.nih.gov/pubmed/37179906 http://dx.doi.org/10.21037/qims-22-780 |
work_keys_str_mv | AT jiaxuan applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase AT wangwenqi applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase AT liangjiawei applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase AT maxiaohui applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase AT chenweibo applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase AT wudan applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase AT zhanghongxi applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase AT nishaoqing applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase AT wujiheng applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase AT laican applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase AT zhangyi applicationofamideprotontransferimagingtopretreatmentriskstratificationofchildhoodneuroblastomacomparisonwithneuronspecificenolase |