A stimulus‐contingent positive feedback loop enables IFN‐β dose‐dependent activation of pro‐inflammatory genes

Type I interferons (IFN) induce powerful antiviral and innate immune responses via the transcription factor, IFN‐stimulated gene factor (ISGF3). However, in some pathological contexts, type I IFNs are responsible for exacerbating inflammation. Here, we show that a high dose of IFN‐β also activates a...

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Detalles Bibliográficos
Autores principales: Wilder, Catera L, Lefaudeux, Diane, Mathenge, Raisa, Kishimoto, Kensei, Zuniga Munoz, Alma, Nguyen, Minh A, Meyer, Aaron S, Cheng, Quen J, Hoffmann, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167482/
https://www.ncbi.nlm.nih.gov/pubmed/36929731
http://dx.doi.org/10.15252/msb.202211294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167482/
https://www.ncbi.nlm.nih.gov/pubmed/36929731
http://dx.doi.org/10.15252/msb.202211294

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