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Irreversible electroporation of the pancreas – A decade on
Irreversible electroporation (IRE) employs the use of an electric field to cause irreversible permeability of the cell membrane, inducing apoptosis. The use of IRE for locally advanced pancreatic cancer (LAPC) was first described in 2012. The crucial advantage of IRE compared with other devices empl...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shanghai Journal of Interventional Radiology Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167507/ https://www.ncbi.nlm.nih.gov/pubmed/37180371 http://dx.doi.org/10.1016/j.jimed.2022.10.001 |
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author | Ong, Daniel Yuxuan How, Guo Yuan Pua, Uei |
author_facet | Ong, Daniel Yuxuan How, Guo Yuan Pua, Uei |
author_sort | Ong, Daniel Yuxuan |
collection | PubMed |
description | Irreversible electroporation (IRE) employs the use of an electric field to cause irreversible permeability of the cell membrane, inducing apoptosis. The use of IRE for locally advanced pancreatic cancer (LAPC) was first described in 2012. The crucial advantage of IRE compared with other devices employing thermal ablation is the safety around vital structures such as vessels and ducts. This makes it an attractive option for use in the pancreas due to the close proximity of multiple major vascular structures, biliary ducts, and adjacent gastrointestinal organs. Over the past decade, IRE has established itself as a useful treatment adjunct and may soon become the standard of care, particularly for LAPC. This article will explore the current evidence and provide a concise summary of pertinent issues, including patient selection, preoperative management, clinical outcomes, radiological response and future prospects of IRE in pancreatic cancer. |
format | Online Article Text |
id | pubmed-10167507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Shanghai Journal of Interventional Radiology Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-101675072023-05-10 Irreversible electroporation of the pancreas – A decade on Ong, Daniel Yuxuan How, Guo Yuan Pua, Uei J Interv Med Article Irreversible electroporation (IRE) employs the use of an electric field to cause irreversible permeability of the cell membrane, inducing apoptosis. The use of IRE for locally advanced pancreatic cancer (LAPC) was first described in 2012. The crucial advantage of IRE compared with other devices employing thermal ablation is the safety around vital structures such as vessels and ducts. This makes it an attractive option for use in the pancreas due to the close proximity of multiple major vascular structures, biliary ducts, and adjacent gastrointestinal organs. Over the past decade, IRE has established itself as a useful treatment adjunct and may soon become the standard of care, particularly for LAPC. This article will explore the current evidence and provide a concise summary of pertinent issues, including patient selection, preoperative management, clinical outcomes, radiological response and future prospects of IRE in pancreatic cancer. Shanghai Journal of Interventional Radiology Press 2022-10-22 /pmc/articles/PMC10167507/ /pubmed/37180371 http://dx.doi.org/10.1016/j.jimed.2022.10.001 Text en © 2022 Shanghai Journal of Interventional Radiology Press. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Ong, Daniel Yuxuan How, Guo Yuan Pua, Uei Irreversible electroporation of the pancreas – A decade on |
title | Irreversible electroporation of the pancreas – A decade on |
title_full | Irreversible electroporation of the pancreas – A decade on |
title_fullStr | Irreversible electroporation of the pancreas – A decade on |
title_full_unstemmed | Irreversible electroporation of the pancreas – A decade on |
title_short | Irreversible electroporation of the pancreas – A decade on |
title_sort | irreversible electroporation of the pancreas – a decade on |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167507/ https://www.ncbi.nlm.nih.gov/pubmed/37180371 http://dx.doi.org/10.1016/j.jimed.2022.10.001 |
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