Effectiveness of Genotype-Specific Tricyclic Antidepressant Dosing in Patients With Major Depressive Disorder: A Randomized Clinical Trial

IMPORTANCE: Evidence of the clinical benefit of pharmacogenetics-informed treatment (PIT) with antidepressants is still limited. Especially for tricyclic antidepressants (TCAs), pharmacogenetics may be of interest because therapeutic plasma concentrations are well defined, identification of optimal...

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Detalles Bibliográficos
Autores principales: Vos, Cornelis F., ter Hark, Sophie E., Schellekens, Arnt F. A., Spijker, Jan, van der Meij, Annemarie, Grotenhuis, Anne J., Mihaescu, Raluca, Kievit, Wietske, Donders, Rogier, Aarnoutse, Rob E., Coenen, Marieke J. H., Janzing, Joost G. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167565/
https://www.ncbi.nlm.nih.gov/pubmed/37155164
http://dx.doi.org/10.1001/jamanetworkopen.2023.12443

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