Nivolumab‐induced fatal myocarditis: A case report

KEY CLINICAL MESSAGE: Baseline assessment and interval monitoring with a careful history, clinical examination, laboratory work‐up, and noninvasive imaging modalities may be beneficial for early detection of immune checkpoint inhibitor‐associated side effects. ABSTRACT: Previous reports of immune ch...

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Detalles Bibliográficos
Autores principales: Bharathidasan, Kavya, Abdelnabi, Mahmoud, Abdelmalek, John, Sekhon, Jasmine, Butler, William, Quirch, Miguel, Sosa, Erwin Argueta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167613/
https://www.ncbi.nlm.nih.gov/pubmed/37180331
http://dx.doi.org/10.1002/ccr3.7306
Descripción
Sumario:KEY CLINICAL MESSAGE: Baseline assessment and interval monitoring with a careful history, clinical examination, laboratory work‐up, and noninvasive imaging modalities may be beneficial for early detection of immune checkpoint inhibitor‐associated side effects. ABSTRACT: Previous reports of immune checkpoint inhibitors' cardiotoxic effects include pericarditis, myocarditis, myocardial infarction, ventricular dysfunction, vasculitis, and electrical abnormalities. The authors report a case of acute heart failure caused by nivolumab‐induced cardiotoxicity in a middle‐aged man with advanced esophageal carcinoma with no previous cardiac history or significant cardiovascular risk factors.

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