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Computer-aided design of a cyclic di-AMP synthesizing enzyme CdaA inhibitor

Cyclic di-AMP (c-di-AMP) is an essential secondary messenger regulating cell wall homeostasis and myriads of physiological processes in several Gram-positive and mycobacteria, including human pathogens. Hence, c-di-AMP synthesizing enzymes (DACs) have become a promising antibacterial drug target. To...

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Detalles Bibliográficos
Autores principales:	Neumann, Piotr, Kloskowski, Patrick, Ficner, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167629/ https://www.ncbi.nlm.nih.gov/pubmed/37223749 http://dx.doi.org/10.1093/femsml/uqad021

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