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“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review

OBJECTIVES: The aim of this systematic review was to summarize the available literature on gut microbiome (GMB) and osteoarthritis (OA), analyze the correlation between GMB and OA, and explore potential underlying mechanisms. METHODS: A systematic search of the PubMed, Embase, Cochrane, and Web of S...

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Autores principales: Liu, Su, Li, Guoqing, Xu, Huihui, Wang, Qichang, Wei, Yihao, Yang, Qi, Xiong, Ao, Yu, Fei, Weng, Jian, Zeng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167637/
https://www.ncbi.nlm.nih.gov/pubmed/37180142
http://dx.doi.org/10.3389/fimmu.2023.1150572
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author Liu, Su
Li, Guoqing
Xu, Huihui
Wang, Qichang
Wei, Yihao
Yang, Qi
Xiong, Ao
Yu, Fei
Weng, Jian
Zeng, Hui
author_facet Liu, Su
Li, Guoqing
Xu, Huihui
Wang, Qichang
Wei, Yihao
Yang, Qi
Xiong, Ao
Yu, Fei
Weng, Jian
Zeng, Hui
author_sort Liu, Su
collection PubMed
description OBJECTIVES: The aim of this systematic review was to summarize the available literature on gut microbiome (GMB) and osteoarthritis (OA), analyze the correlation between GMB and OA, and explore potential underlying mechanisms. METHODS: A systematic search of the PubMed, Embase, Cochrane, and Web of Science with the keywords “Gut Microbiome” and “Osteoarthritis” was conducted to identify the human and animal studies exploring the association between GMB and OA. The retrieval time range was from the database inception to July 31, 2022. Studies reported the other arthritic diseases without OA, reviews, and studies focused on the microbiome in other parts of the body with OA, such as oral or skin, were excluded. The included studies were mainly reviewed for GMB composition, OA severity, inflammatory factors, and intestinal permeability. RESULTS: There were 31 studies published met the inclusion criteria and were analyzed, including 10 human studies and 21 animal studies. Human and animal studies have reached a consistent conclusion that GMB dysbiosis could aggravate OA. In addition, several studies have found that alterations of GMB composition can increase intestinal permeability and serum levels of inflammatory factors, while regulating GMB can alleviate the changes. Owing to the susceptibility of GMB to internal and external environments, genetics, and geography, the included studies were not consistent in GMB composition analysis. CONCLUSION: There is a lack of high-quality studies evaluating the effects of GMB on OA. Available evidence indicated that GMB dysbiosis aggravated OA through activating the immune response and subsequent induction of inflammation. Future studies should focus on more prospective, cohort studies combined with multi-omics to further clarify the correlation.
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spelling pubmed-101676372023-05-10 “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review Liu, Su Li, Guoqing Xu, Huihui Wang, Qichang Wei, Yihao Yang, Qi Xiong, Ao Yu, Fei Weng, Jian Zeng, Hui Front Immunol Immunology OBJECTIVES: The aim of this systematic review was to summarize the available literature on gut microbiome (GMB) and osteoarthritis (OA), analyze the correlation between GMB and OA, and explore potential underlying mechanisms. METHODS: A systematic search of the PubMed, Embase, Cochrane, and Web of Science with the keywords “Gut Microbiome” and “Osteoarthritis” was conducted to identify the human and animal studies exploring the association between GMB and OA. The retrieval time range was from the database inception to July 31, 2022. Studies reported the other arthritic diseases without OA, reviews, and studies focused on the microbiome in other parts of the body with OA, such as oral or skin, were excluded. The included studies were mainly reviewed for GMB composition, OA severity, inflammatory factors, and intestinal permeability. RESULTS: There were 31 studies published met the inclusion criteria and were analyzed, including 10 human studies and 21 animal studies. Human and animal studies have reached a consistent conclusion that GMB dysbiosis could aggravate OA. In addition, several studies have found that alterations of GMB composition can increase intestinal permeability and serum levels of inflammatory factors, while regulating GMB can alleviate the changes. Owing to the susceptibility of GMB to internal and external environments, genetics, and geography, the included studies were not consistent in GMB composition analysis. CONCLUSION: There is a lack of high-quality studies evaluating the effects of GMB on OA. Available evidence indicated that GMB dysbiosis aggravated OA through activating the immune response and subsequent induction of inflammation. Future studies should focus on more prospective, cohort studies combined with multi-omics to further clarify the correlation. Frontiers Media S.A. 2023-04-25 /pmc/articles/PMC10167637/ /pubmed/37180142 http://dx.doi.org/10.3389/fimmu.2023.1150572 Text en Copyright © 2023 Liu, Li, Xu, Wang, Wei, Yang, Xiong, Yu, Weng and Zeng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Su
Li, Guoqing
Xu, Huihui
Wang, Qichang
Wei, Yihao
Yang, Qi
Xiong, Ao
Yu, Fei
Weng, Jian
Zeng, Hui
“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review
title “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review
title_full “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review
title_fullStr “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review
title_full_unstemmed “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review
title_short “Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review
title_sort “cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167637/
https://www.ncbi.nlm.nih.gov/pubmed/37180142
http://dx.doi.org/10.3389/fimmu.2023.1150572
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