Highly Diastereoselective Multicomponent Synthesis of Spirocyclopropyl Oxindoles Enabled by Rare-Earth Metal Salts

[Image: see text] The synthesis of polysubstituted spirocyclopropyl oxindoles using a series of rare-earth metal (REM) salts is reported. REMs, in particular Sc(OTf)(3), allowed access to the target compounds by a multicomponent reaction with high diastereoselectivity (≤94:6:0:0). Density functional...

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Detalles Bibliográficos
Autores principales: Tallarida, Matteo A., Olivito, Fabrizio, Navo, Claudio D., Algieri, Vincenzo, Jiritano, Antonio, Costanzo, Paola, Poveda, Ana, Moure, Maria J., Jiménez-Barbero, Jesús, Maiuolo, Loredana, Jiménez-Osés, Gonzalo, De Nino, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167684/
https://www.ncbi.nlm.nih.gov/pubmed/37125666
http://dx.doi.org/10.1021/acs.orglett.3c00772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167684/
https://www.ncbi.nlm.nih.gov/pubmed/37125666
http://dx.doi.org/10.1021/acs.orglett.3c00772

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