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Correlated Somatosensory Input in Parvalbumin/Pyramidal Cells in Mouse Motor Cortex

In mammalian cortex, feedforward excitatory connections recruit feedforward inhibition. This is often carried by parvalbumin (PV+) interneurons, which may densely connect to local pyramidal (Pyr) neurons. Whether this inhibition affects all local excitatory cells indiscriminately or is targeted to s...

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Autores principales: Goz, Roman U., Hooks, Bryan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167893/
https://www.ncbi.nlm.nih.gov/pubmed/37094939
http://dx.doi.org/10.1523/ENEURO.0488-22.2023
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author Goz, Roman U.
Hooks, Bryan M.
author_facet Goz, Roman U.
Hooks, Bryan M.
author_sort Goz, Roman U.
collection PubMed
description In mammalian cortex, feedforward excitatory connections recruit feedforward inhibition. This is often carried by parvalbumin (PV+) interneurons, which may densely connect to local pyramidal (Pyr) neurons. Whether this inhibition affects all local excitatory cells indiscriminately or is targeted to specific subnetworks is unknown. Here, we test how feedforward inhibition is recruited by using two-channel circuit mapping to excite cortical and thalamic inputs to PV+ interneurons and Pyr neurons to mouse primary vibrissal motor cortex (M1). Single Pyr and PV+ neurons receive input from both cortex and thalamus. Connected pairs of PV+ interneurons and excitatory Pyr neurons receive correlated cortical and thalamic inputs. While PV+ interneurons are more likely to form local connections to Pyr neurons, Pyr neurons are much more likely to form reciprocal connections with PV+ interneurons that inhibit them. This suggests that Pyr and PV ensembles may be organized based on their local and long-range connections, an organization that supports the idea of local subnetworks for signal transduction and processing. Excitatory inputs to M1 can thus target inhibitory networks in a specific pattern which permits recruitment of feedforward inhibition to specific subnetworks within the cortical column.
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spelling pubmed-101678932023-05-10 Correlated Somatosensory Input in Parvalbumin/Pyramidal Cells in Mouse Motor Cortex Goz, Roman U. Hooks, Bryan M. eNeuro Research Article: New Research In mammalian cortex, feedforward excitatory connections recruit feedforward inhibition. This is often carried by parvalbumin (PV+) interneurons, which may densely connect to local pyramidal (Pyr) neurons. Whether this inhibition affects all local excitatory cells indiscriminately or is targeted to specific subnetworks is unknown. Here, we test how feedforward inhibition is recruited by using two-channel circuit mapping to excite cortical and thalamic inputs to PV+ interneurons and Pyr neurons to mouse primary vibrissal motor cortex (M1). Single Pyr and PV+ neurons receive input from both cortex and thalamus. Connected pairs of PV+ interneurons and excitatory Pyr neurons receive correlated cortical and thalamic inputs. While PV+ interneurons are more likely to form local connections to Pyr neurons, Pyr neurons are much more likely to form reciprocal connections with PV+ interneurons that inhibit them. This suggests that Pyr and PV ensembles may be organized based on their local and long-range connections, an organization that supports the idea of local subnetworks for signal transduction and processing. Excitatory inputs to M1 can thus target inhibitory networks in a specific pattern which permits recruitment of feedforward inhibition to specific subnetworks within the cortical column. Society for Neuroscience 2023-05-05 /pmc/articles/PMC10167893/ /pubmed/37094939 http://dx.doi.org/10.1523/ENEURO.0488-22.2023 Text en Copyright © 2023 Goz and Hooks https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Goz, Roman U.
Hooks, Bryan M.
Correlated Somatosensory Input in Parvalbumin/Pyramidal Cells in Mouse Motor Cortex
title Correlated Somatosensory Input in Parvalbumin/Pyramidal Cells in Mouse Motor Cortex
title_full Correlated Somatosensory Input in Parvalbumin/Pyramidal Cells in Mouse Motor Cortex
title_fullStr Correlated Somatosensory Input in Parvalbumin/Pyramidal Cells in Mouse Motor Cortex
title_full_unstemmed Correlated Somatosensory Input in Parvalbumin/Pyramidal Cells in Mouse Motor Cortex
title_short Correlated Somatosensory Input in Parvalbumin/Pyramidal Cells in Mouse Motor Cortex
title_sort correlated somatosensory input in parvalbumin/pyramidal cells in mouse motor cortex
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167893/
https://www.ncbi.nlm.nih.gov/pubmed/37094939
http://dx.doi.org/10.1523/ENEURO.0488-22.2023
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