Cargando…

Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes. The main pathological changes were intestinal mucosal injury. Leucine-rich repeat-containing G protein coupled receptor 5 (LGR5)-labeled small intestine stem cells (ISCs) were located at the bottom of the smal...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Lie, Duan, Sheng-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167905/
https://www.ncbi.nlm.nih.gov/pubmed/37179583
http://dx.doi.org/10.3748/wjg.v29.i16.2380
_version_ 1785038763421859840
author Zheng, Lie
Duan, Sheng-Lei
author_facet Zheng, Lie
Duan, Sheng-Lei
author_sort Zheng, Lie
collection PubMed
description Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes. The main pathological changes were intestinal mucosal injury. Leucine-rich repeat-containing G protein coupled receptor 5 (LGR5)-labeled small intestine stem cells (ISCs) were located at the bottom of the small intestine recess and inlaid among Paneth cells. LGR5+ small ISCs are active proliferative adult stem cells, and their self-renewal, proliferation and differentiation disorders are closely related to the occurrence of intestinal inflammatory diseases. The Notch signaling pathway and Wnt/β-catenin signaling pathway are important regulators of LGR5-positive ISCs and together maintain the function of LGR5-positive ISCs. More importantly, the surviving stem cells after intestinal mucosal injury accelerate division, restore the number of stem cells, multiply and differentiate into mature intestinal epithelial cells, and repair the damaged intestinal mucosa. Therefore, in-depth study of multiple pathways and transplantation of LGR5-positive ISCs may become a new target for the treatment of UC.
format Online
Article
Text
id pubmed-10167905
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-101679052023-05-10 Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis Zheng, Lie Duan, Sheng-Lei World J Gastroenterol Review Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes. The main pathological changes were intestinal mucosal injury. Leucine-rich repeat-containing G protein coupled receptor 5 (LGR5)-labeled small intestine stem cells (ISCs) were located at the bottom of the small intestine recess and inlaid among Paneth cells. LGR5+ small ISCs are active proliferative adult stem cells, and their self-renewal, proliferation and differentiation disorders are closely related to the occurrence of intestinal inflammatory diseases. The Notch signaling pathway and Wnt/β-catenin signaling pathway are important regulators of LGR5-positive ISCs and together maintain the function of LGR5-positive ISCs. More importantly, the surviving stem cells after intestinal mucosal injury accelerate division, restore the number of stem cells, multiply and differentiate into mature intestinal epithelial cells, and repair the damaged intestinal mucosa. Therefore, in-depth study of multiple pathways and transplantation of LGR5-positive ISCs may become a new target for the treatment of UC. Baishideng Publishing Group Inc 2023-04-28 2023-04-28 /pmc/articles/PMC10167905/ /pubmed/37179583 http://dx.doi.org/10.3748/wjg.v29.i16.2380 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Zheng, Lie
Duan, Sheng-Lei
Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis
title Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis
title_full Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis
title_fullStr Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis
title_full_unstemmed Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis
title_short Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis
title_sort molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167905/
https://www.ncbi.nlm.nih.gov/pubmed/37179583
http://dx.doi.org/10.3748/wjg.v29.i16.2380
work_keys_str_mv AT zhenglie molecularregulationmechanismofintestinalstemcellsinmucosalinjuryandrepairinulcerativecolitis
AT duanshenglei molecularregulationmechanismofintestinalstemcellsinmucosalinjuryandrepairinulcerativecolitis