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EB-OCT: a potential strategy on early diagnosis and treatment for lung cancer

Lung cancer is the leading cause of cancer-related death in China and the world, mainly attributed to delayed diagnosis, given that currently available early screening strategies exhibit limited value. Endobronchial optical coherence tomography (EB-OCT) has the characteristics of non-invasiveness, a...

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Autores principales: Long, Hang, Ji, Jiaqi, Chen, Lijuan, Feng, Jiayue, Liao, Jie, Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168178/
https://www.ncbi.nlm.nih.gov/pubmed/37182131
http://dx.doi.org/10.3389/fonc.2023.1156218
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author Long, Hang
Ji, Jiaqi
Chen, Lijuan
Feng, Jiayue
Liao, Jie
Yang, Yang
author_facet Long, Hang
Ji, Jiaqi
Chen, Lijuan
Feng, Jiayue
Liao, Jie
Yang, Yang
author_sort Long, Hang
collection PubMed
description Lung cancer is the leading cause of cancer-related death in China and the world, mainly attributed to delayed diagnosis, given that currently available early screening strategies exhibit limited value. Endobronchial optical coherence tomography (EB-OCT) has the characteristics of non-invasiveness, accuracy, and repeatability. Importantly, the combination of EB-OCT with existing technologies represents a potential approach for early screening and diagnosis. In this review, we introduce the structure and strengths of EB-OCT. Furthermore, we provide a comprehensive overview of the application of EB-OCT on early screening and diagnosis of lung cancer from in vivo experiments to clinical studies, including differential diagnosis of airway lesions, early screening for lung cancer, lung nodules, lymph node biopsy and localization and palliative treatment of lung cancer. Moreover, the bottlenecks and difficulties in developing and popularizing EB-OCT for diagnosis and treatment during clinical practice are analyzed. The characteristics of OCT images of normal and cancerous lung tissues were in good agreement with the results of pathology, which could be used to judge the nature of lung lesions in real time. In addition, EB-OCT can be used as an assistant to biopsy of pulmonary nodules and improve the success rate of biopsy. EB-OCT also plays an auxiliary role in the treatment of lung cancer. In conclusion, EB-OCT is non-invasive, safe and accurate in real-time. It is of great significance in the diagnosis of lung cancer and suitable for clinical application and is expected to become an important diagnostic method for lung cancer in the future.
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spelling pubmed-101681782023-05-10 EB-OCT: a potential strategy on early diagnosis and treatment for lung cancer Long, Hang Ji, Jiaqi Chen, Lijuan Feng, Jiayue Liao, Jie Yang, Yang Front Oncol Oncology Lung cancer is the leading cause of cancer-related death in China and the world, mainly attributed to delayed diagnosis, given that currently available early screening strategies exhibit limited value. Endobronchial optical coherence tomography (EB-OCT) has the characteristics of non-invasiveness, accuracy, and repeatability. Importantly, the combination of EB-OCT with existing technologies represents a potential approach for early screening and diagnosis. In this review, we introduce the structure and strengths of EB-OCT. Furthermore, we provide a comprehensive overview of the application of EB-OCT on early screening and diagnosis of lung cancer from in vivo experiments to clinical studies, including differential diagnosis of airway lesions, early screening for lung cancer, lung nodules, lymph node biopsy and localization and palliative treatment of lung cancer. Moreover, the bottlenecks and difficulties in developing and popularizing EB-OCT for diagnosis and treatment during clinical practice are analyzed. The characteristics of OCT images of normal and cancerous lung tissues were in good agreement with the results of pathology, which could be used to judge the nature of lung lesions in real time. In addition, EB-OCT can be used as an assistant to biopsy of pulmonary nodules and improve the success rate of biopsy. EB-OCT also plays an auxiliary role in the treatment of lung cancer. In conclusion, EB-OCT is non-invasive, safe and accurate in real-time. It is of great significance in the diagnosis of lung cancer and suitable for clinical application and is expected to become an important diagnostic method for lung cancer in the future. Frontiers Media S.A. 2023-04-25 /pmc/articles/PMC10168178/ /pubmed/37182131 http://dx.doi.org/10.3389/fonc.2023.1156218 Text en Copyright © 2023 Long, Ji, Chen, Feng, Liao and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Long, Hang
Ji, Jiaqi
Chen, Lijuan
Feng, Jiayue
Liao, Jie
Yang, Yang
EB-OCT: a potential strategy on early diagnosis and treatment for lung cancer
title EB-OCT: a potential strategy on early diagnosis and treatment for lung cancer
title_full EB-OCT: a potential strategy on early diagnosis and treatment for lung cancer
title_fullStr EB-OCT: a potential strategy on early diagnosis and treatment for lung cancer
title_full_unstemmed EB-OCT: a potential strategy on early diagnosis and treatment for lung cancer
title_short EB-OCT: a potential strategy on early diagnosis and treatment for lung cancer
title_sort eb-oct: a potential strategy on early diagnosis and treatment for lung cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168178/
https://www.ncbi.nlm.nih.gov/pubmed/37182131
http://dx.doi.org/10.3389/fonc.2023.1156218
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