Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk

The abundance of Lp(a) protein holds significant implications for the risk of cardiovascular disease (CVD), which is directly impacted by the copy number (CN) of KIV-2, a 5.5 kbp sub-region. KIV-2 is highly polymorphic in the population and accurate analysis is challenging. In this study, we present...

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Detalles Bibliográficos
Autores principales: Behera, S., Belyeu, J. R., Chen, X., Paulin, L. F., Nguyen, N.Q.H., Newman, E., Mahmoud, M., Menon, V. K., Qi, Q., Joshi, P., Marcovina, S., Rossi, M., Roller, E., Han, J., Onuchic, V., Avery, C. L., Ballantyne, C.M., Rodriguez, C. J., Kaplan, R. C., Muzny, D. M., Metcalf, G. A., Gibbs, R., Yu, B., Boerwinkle, E., Eberle, M. A., Sedlazeck, F. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168217/
https://www.ncbi.nlm.nih.gov/pubmed/37163057
http://dx.doi.org/10.1101/2023.04.24.538128

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