Long lifetime and selective accumulation of the A-type lamins accounts for the tissue specificity of Hutchinson-Gilford progeria syndrome

Mutations to the LMNA gene cause laminopathies including Hutchinson-Gilford progeria syndrome (HGPS) that severely affect the cardiovascular system. The origins of tissue specificity in these diseases are unclear, as the A-type Lamins are abundant and broadly expressed proteins. We show that A-type...

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Detalles Bibliográficos
Autores principales: Hasper, John, Welle, Kevin, Swovick, Kyle, Hryhorenko, Jennifer, Ghaemmaghami, Sina, Buchwalter, Abigail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168242/
https://www.ncbi.nlm.nih.gov/pubmed/37162946
http://dx.doi.org/10.1101/2023.02.04.527139

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