Chemical screens in aging-relevant human motor neurons identify MAP4Ks as therapeutic targets for amyotrophic lateral sclerosis

Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease mainly affecting motor neurons. By screening chemical compounds in human patient-derived and aging-relevant motor neurons, we identify a neuroprotective compound and show that MAP4...

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Detalles Bibliográficos
Autores principales: Liu, Meng-Lu, Ma, Shuaipeng, Tai, Wenjiao, Zhong, Xiaoling, Ni, Haoqi, Zou, Yuhua, Wang, Jingcheng, Zhang, Chun-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168247/
https://www.ncbi.nlm.nih.gov/pubmed/37162962
http://dx.doi.org/10.1101/2023.04.24.538014

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