Inosine Induces Stemness Features in CAR T cells and Enhances Potency

Adenosine (Ado) mediates immune suppression in the tumor microenvironment and exhausted CD8(+) CAR T cells mediate Ado-induced immunosuppression through CD39/73-dependent Ado production. Knockout of CD39, CD73 or A2aR had modest effects on exhausted CAR T cells, whereas overexpression of Ado deamina...

Descripción completa

Detalles Bibliográficos
Autores principales: Klysz, Dorota D., Fowler, Carley, Malipatlolla, Meena, Stuani, Lucille, Freitas, Katherine A., Meier, Stefanie, Daniel, Bence, Sandor, Katalin, Xu, Peng, Huang, Jing, Labanieh, Louai, Leruste, Amaury, Bashti, Malek, Keerthi, Vimal, Mata-Alcazar, Janette, Gkitsas, Nikolaos, Guerrero, Justin A., Fisher, Chris, Patel, Sunny, Asano, Kyle, Patel, Shabnum, Davis, Kara L., Satpathy, Ansuman T., Feldman, Steven A., Sotillo, Elena, Mackall, Crystal L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168291/
https://www.ncbi.nlm.nih.gov/pubmed/37162847
http://dx.doi.org/10.1101/2023.04.21.537859

Ejemplares similares

Ejemplares similares