Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

Besides its mitochondria-based anti-apoptotic role, Bcl-xL also travels to the nucleus to promote cancer metastasis by upregulating global histone H3 trimethyl Lys4 (H3K4me3) and TGFβ transcription. How Bcl-xL is translocated into the nucleus and how nuclear Bcl-xL regulates H3K4me3 modification are...

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Detalles Bibliográficos
Autores principales: Zhang, Tiantian, Li, Sha, Tan, Yingcai Adrian, Na, Joseph HyungJoon, Chen, Zhengming, Damle, Priyadarshan, Chen, Xiang, Choi, Soyoung, Mishra, Bikash, Wang, Dunrui, Grossman, Steven R., Jiang, Xuejun, Li, Yi, Chen, Yao-Tseng, Xiang, Jenny Z., Du, Yi-Chieh Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168309/
https://www.ncbi.nlm.nih.gov/pubmed/37163116
http://dx.doi.org/10.1101/2023.04.26.538373

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