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A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na(+) Channels

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Fast Inactivation in voltage-gated Na(+) channels plays essential roles in numerous physiological functions. The canonical hinged-lid model has long predicted that a hydrophobic motif in the DIII-DIV linker (IFM) acts as the gating particle that occludes the permeation pathway during fast inactivati...

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Detalles Bibliográficos
Autores principales:	Liu, Yichen, Bassetto, Carlos A Z, Pinto, Bernardo I, Bezanilla, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168311/ https://www.ncbi.nlm.nih.gov/pubmed/37162849 http://dx.doi.org/10.1101/2023.04.27.538555

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