Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy

The μ-opioid receptor (μOR) is an important target for pain management and the molecular understanding of drug action will facilitate the development of better therapeutics. Here we show, using double electron-electron resonance (DEER) and single-molecule fluorescence resonance energy transfer (smFR...

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Detalles Bibliográficos
Autores principales: Zhao, Jiawei, Elgeti, Matthias, O’Brien, Evan S., Sár, Cecília P., EI Daibani, Amal, Heng, Jie, Sun, Xiaoou, Che, Tao, Hubbell, Wayne L., Kobilka, Brian K., Chen, Chunlai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168371/
https://www.ncbi.nlm.nih.gov/pubmed/37163120
http://dx.doi.org/10.1101/2023.04.28.538657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168371/
https://www.ncbi.nlm.nih.gov/pubmed/37163120
http://dx.doi.org/10.1101/2023.04.28.538657

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