An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types

5-fluorouracil (5-FU) is a successful and broadly used anti-cancer therapeutic. A major mechanism of action of 5-FU is thought to be through thymidylate synthase (TYMS) inhibition resulting in dTTP depletion and activation of the DNA damage response. This suggests that 5-FU should synergize with oth...

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Detalles Bibliográficos
Autores principales: Chen, Jung-Kuei, Merrick, Karl A., Kong, Yi Wen, Izrael-Tomasevic, Anita, Eng, George, Handly, Erika D., Patterson, Jesse C., Cannell, Ian G., Suarez-Lopez, Lucia, Hosios, Aaron M., Dinh, Anh, Kirkpatrick, Donald S., Yu, Kebing, Rose, Christopher M., Hernandez, Jonathan M., Hwangbo, Haeun, Palmer, Adam C., Vander Heiden, Matthew G., Yilmaz, Ömer H., Yaffe, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168374/
https://www.ncbi.nlm.nih.gov/pubmed/37162991
http://dx.doi.org/10.1101/2023.04.28.538590

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