Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift

Developing broad coronavirus vaccines requires identifying and understanding the molecular basis of broadly neutralizing antibody (bnAb) spike sites. In our previous work, we identified sarbecovirus spike RBD group 1 and 2 bnAbs. We have now shown that many of these bnAbs can still neutralize highly...

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Detalles Bibliográficos
Autores principales: Song, Ge, Yuan, Meng, Liu, Hejun, Capozzola, Tazio, Lin, Ryan N., Torres, Jonathan L., He, Wan-ting, Musharrafieh, Rami, Dueker, Katharina, Zhou, Panpan, Callaghan, Sean, Mishra, Nitesh, Yong, Peter, Anzanello, Fabio, Avillion, Gabriel, Vo, Anh Lina, Li, Xuduo, Makhdoomi, Muzamil, Feng, Ziqi, Zhu, Xueyong, Peng, Linghang, Nemazee, David, Safonova, Yana, Briney, Bryan, Ward, Andrew B, Burton, Dennis R., Wilson, Ian A., Andrabi, Raiees
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168401/
https://www.ncbi.nlm.nih.gov/pubmed/37162858
http://dx.doi.org/10.1101/2023.04.26.538488

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