The LRRK2 kinase substrates Rab8a and Rab10 contribute complementary but distinct disease-relevant phenotypes in human neurons

Mutations in the LRRK2 gene cause familial Parkinson’s disease presenting with pleomorphic neuropathology that can involve α-synuclein or tau accumulation. LRRK2 mutations are thought to converge toward a pathogenic increase in LRRK2 kinase activity. A subset of small Rab GTPases have been identifie...

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Detalles Bibliográficos
Autores principales: Mamais, Adamantios, Sanyal, Anwesha, Fajfer, Austin, Zykoski, Catherine G., Guldin, Michael, Riley-DiPaolo, Alexis, Subrahmanian, Nitya, Gibbs, Whitney, Lin, Steven, LaVoie, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168414/
https://www.ncbi.nlm.nih.gov/pubmed/37163109
http://dx.doi.org/10.1101/2023.04.30.538317

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