Chromatin structure and context-dependent sequence features control prime editing efficiency

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Prime editor (PE) is a highly versatile CRISPR-Cas9 genome editing technique. The current constructs, however, have variable efficiency and may require laborious experimental optimization. This study presents statistical models for learning the salient epigenomic and sequence features of target site...

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Detalles Bibliográficos
Autores principales: Kim, Somang, Yuan, Jimmy B., Woods, Wendy S., Newton, Destry A., Perez-Pinera, Pablo, Song, Jun S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168420/
https://www.ncbi.nlm.nih.gov/pubmed/37162994
http://dx.doi.org/10.1101/2023.04.15.536944

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