PRAME induces genomic instability in uveal melanoma

PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in many cancer types in association with aneuploidy and metastasis. Here, we show that PRAME is expressed predominantly in spermatogonia around the time of meiotic crossing-over in...

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Detalles Bibliográficos
Autores principales: Kurtenbach, Stefan, Sanchez, Margaret I., Kuznetsoff, Jeffim, Rodriguez, Daniel A., Weich, Natalia, Dollar, James, Cruz, Anthony, Kurtenbach, Sarah, Field, Matthew G., Durante, Michael A., Decatur, Christina, Sorouri, Mahsa, Lai, Fan, Shiekhattar, Ramin, Pelaez, Daniel, Correa, Zelia M., Verdun, Ramiro E., Harbour, J. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168463/
https://www.ncbi.nlm.nih.gov/pubmed/37162820
http://dx.doi.org/10.21203/rs.3.rs-2861359/v1

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