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Targeting Sex Determination to Suppress Mosquito Populations

Each year, hundreds of millions of people are infected with arboviruses such as dengue, yellow fever, chikungunya, and Zika, which are all primarily spread by the notorious mosquito Aedes aegypti. Traditional control measures have proven insuficient, necessitating innovations. In response, here we g...

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Detalles Bibliográficos
Autores principales: Akbari, Omar, Li, Ming, Kandul, Nikolay, Sun, Ruichen, Yang, Ting, Dalla Benetta, Elena, Brogan, Daniel, antoshechkin, igor, Sánchez C, Héctor, Zhan, Yin Peng, DeBeaubien, Nicolas, Loh, YuMin, Su, Matthew, Montell, Craig, Marshall, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168471/
https://www.ncbi.nlm.nih.gov/pubmed/37162925
http://dx.doi.org/10.21203/rs.3.rs-2834069/v1
Descripción
Sumario:Each year, hundreds of millions of people are infected with arboviruses such as dengue, yellow fever, chikungunya, and Zika, which are all primarily spread by the notorious mosquito Aedes aegypti. Traditional control measures have proven insuficient, necessitating innovations. In response, here we generate a next generation CRISPR-based precision-guided sterile insect technique (pgSIT) for Aedes aegypti that disrupts genes essential for sex determination and fertility, producing predominantly sterile males that can be deployed at any life stage. Using mathematical models and empirical testing, we demonstrate that released pgSIT males can effectively compete with, suppress, and eliminate caged mosquito populations. This versatile species-specific platform has the potential for field deployment to control wild populations, safely curtailing disease transmission.