SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice

We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. After two and three doses, a RBD dimer and trimer elicited antibody levels in mice comparable to an RBD-VLP. Furthermore, an Omicron (BA.1) RBD hetero-dimer...

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Autores principales: Love, J., Rodriguez-Aponte, Sergio, Tostanoski, Lisa, Dalvie, Neil, Johnston, Ryan, Jacob-Dolan, Catherine, Powers, Olivia, Hachmann, Nicole, Miller, Jessica, Hall, Kevin, Siamatu, Mazuba, Mazurek, Camille, Surve, Nehalee, Barouch, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168475/
https://www.ncbi.nlm.nih.gov/pubmed/37163131
http://dx.doi.org/10.21203/rs.3.rs-2692315/v1
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author Love, J.
Rodriguez-Aponte, Sergio
Tostanoski, Lisa
Dalvie, Neil
Johnston, Ryan
Jacob-Dolan, Catherine
Powers, Olivia
Hachmann, Nicole
Miller, Jessica
Hall, Kevin
Siamatu, Mazuba
Mazurek, Camille
Surve, Nehalee
Barouch, Dan
author_facet Love, J.
Rodriguez-Aponte, Sergio
Tostanoski, Lisa
Dalvie, Neil
Johnston, Ryan
Jacob-Dolan, Catherine
Powers, Olivia
Hachmann, Nicole
Miller, Jessica
Hall, Kevin
Siamatu, Mazuba
Mazurek, Camille
Surve, Nehalee
Barouch, Dan
author_sort Love, J.
collection PubMed
description We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. After two and three doses, a RBD dimer and trimer elicited antibody levels in mice comparable to an RBD-VLP. Furthermore, an Omicron (BA.1) RBD hetero-dimer induced neutralizing activity similar to the RBD-VLP. A RBD hetero-dimer and RBD-VLP also shows comparable breadth to other SARS-CoV-2 variants-of-concern (VOCs).
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spelling pubmed-101684752023-05-10 SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice Love, J. Rodriguez-Aponte, Sergio Tostanoski, Lisa Dalvie, Neil Johnston, Ryan Jacob-Dolan, Catherine Powers, Olivia Hachmann, Nicole Miller, Jessica Hall, Kevin Siamatu, Mazuba Mazurek, Camille Surve, Nehalee Barouch, Dan Res Sq Article We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. After two and three doses, a RBD dimer and trimer elicited antibody levels in mice comparable to an RBD-VLP. Furthermore, an Omicron (BA.1) RBD hetero-dimer induced neutralizing activity similar to the RBD-VLP. A RBD hetero-dimer and RBD-VLP also shows comparable breadth to other SARS-CoV-2 variants-of-concern (VOCs). American Journal Experts 2023-04-28 /pmc/articles/PMC10168475/ /pubmed/37163131 http://dx.doi.org/10.21203/rs.3.rs-2692315/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Love, J.
Rodriguez-Aponte, Sergio
Tostanoski, Lisa
Dalvie, Neil
Johnston, Ryan
Jacob-Dolan, Catherine
Powers, Olivia
Hachmann, Nicole
Miller, Jessica
Hall, Kevin
Siamatu, Mazuba
Mazurek, Camille
Surve, Nehalee
Barouch, Dan
SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice
title SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice
title_full SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice
title_fullStr SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice
title_full_unstemmed SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice
title_short SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice
title_sort sars-cov-2 rbd dimers elicit response comparable to vlps in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168475/
https://www.ncbi.nlm.nih.gov/pubmed/37163131
http://dx.doi.org/10.21203/rs.3.rs-2692315/v1
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