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SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice

We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. After two and three doses, a RBD dimer and trimer elicited antibody levels in mice comparable to an RBD-VLP. Furthermore, an Omicron (BA.1) RBD hetero-dimer...

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Detalles Bibliográficos
Autores principales:	Love, J., Rodriguez-Aponte, Sergio, Tostanoski, Lisa, Dalvie, Neil, Johnston, Ryan, Jacob-Dolan, Catherine, Powers, Olivia, Hachmann, Nicole, Miller, Jessica, Hall, Kevin, Siamatu, Mazuba, Mazurek, Camille, Surve, Nehalee, Barouch, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168475/ https://www.ncbi.nlm.nih.gov/pubmed/37163131 http://dx.doi.org/10.21203/rs.3.rs-2692315/v1

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