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Male fetuses negatively affect the vitality of the litter and the dam’s metabolic and physiological state in multifetal pregnant ewe

In sheep, ~30% of fetuses do not survive till parturition, and 17.7% of the multifetal pregnancies experience partial litter loss (PLL). In humans, multifetal pregnancies are associated with a higher risk of perinatal mortality. Therefore, the objectives were to examine the association between parti...

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Autores principales: Alon, Tamir, Rosov, Alexander, Lifshitz, Lila, Moallem, Uzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168572/
https://www.ncbi.nlm.nih.gov/pubmed/37159474
http://dx.doi.org/10.1371/journal.pone.0285338
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author Alon, Tamir
Rosov, Alexander
Lifshitz, Lila
Moallem, Uzi
author_facet Alon, Tamir
Rosov, Alexander
Lifshitz, Lila
Moallem, Uzi
author_sort Alon, Tamir
collection PubMed
description In sheep, ~30% of fetuses do not survive till parturition, and 17.7% of the multifetal pregnancies experience partial litter loss (PLL). In humans, multifetal pregnancies are associated with a higher risk of perinatal mortality. Therefore, the objectives were to examine the association between partial litter loss, fetal sex, dam’s metabolic and physiological state, and pregnancy outcome in multifetal pregnant ewes. The study includes two parts. The first was a retrospective study, in which we analyzed data of 675 lambings and examined the PLL incidence according to male ratio (MR) for all litter sizes (range 2–6). Lambings were categorized as having a low male ratio (LMR; <50% males) or a high male ratio (LMR; >50% males). In the second part, we monitored 24 ewes from 80 to 138 days in pregnancy every 10 days, and then daily until lambing, by ultrasound scanning for maternal heart rate (HR), and Doppler ultrasound for litter vitality. Blood samples were taken from dams on the days of scanning. Male ratio strongly affected PLL, where the general survival rate (for all lambings) was reduced from 90% in LMR lambings to 85% in HMR lambings. The odds ratio for PLL in HMR vs. LMR litters was 1.82. Birth body weight and the survival rate of female was higher in LMR than HMR lambings, with no differences for male lambs in both parameters. In the second part, dams’ HR during the last trimester was 9.4% higher in LMR than in HMR pregnancies, with no differences in fetuses’ HR. The plasma glucose and insulin concentrations were not significantly different between groups, but plasma β-hydroxybutyrate and nonesterified fatty acid concentrations were, respectively, 31% and 20% lower in HMR vs. LMR ewes. In conclusion, male fetuses negatively affect pregnancy outcomes and influence dams’ metabolic and physiological state in sheep.
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spelling pubmed-101685722023-05-10 Male fetuses negatively affect the vitality of the litter and the dam’s metabolic and physiological state in multifetal pregnant ewe Alon, Tamir Rosov, Alexander Lifshitz, Lila Moallem, Uzi PLoS One Research Article In sheep, ~30% of fetuses do not survive till parturition, and 17.7% of the multifetal pregnancies experience partial litter loss (PLL). In humans, multifetal pregnancies are associated with a higher risk of perinatal mortality. Therefore, the objectives were to examine the association between partial litter loss, fetal sex, dam’s metabolic and physiological state, and pregnancy outcome in multifetal pregnant ewes. The study includes two parts. The first was a retrospective study, in which we analyzed data of 675 lambings and examined the PLL incidence according to male ratio (MR) for all litter sizes (range 2–6). Lambings were categorized as having a low male ratio (LMR; <50% males) or a high male ratio (LMR; >50% males). In the second part, we monitored 24 ewes from 80 to 138 days in pregnancy every 10 days, and then daily until lambing, by ultrasound scanning for maternal heart rate (HR), and Doppler ultrasound for litter vitality. Blood samples were taken from dams on the days of scanning. Male ratio strongly affected PLL, where the general survival rate (for all lambings) was reduced from 90% in LMR lambings to 85% in HMR lambings. The odds ratio for PLL in HMR vs. LMR litters was 1.82. Birth body weight and the survival rate of female was higher in LMR than HMR lambings, with no differences for male lambs in both parameters. In the second part, dams’ HR during the last trimester was 9.4% higher in LMR than in HMR pregnancies, with no differences in fetuses’ HR. The plasma glucose and insulin concentrations were not significantly different between groups, but plasma β-hydroxybutyrate and nonesterified fatty acid concentrations were, respectively, 31% and 20% lower in HMR vs. LMR ewes. In conclusion, male fetuses negatively affect pregnancy outcomes and influence dams’ metabolic and physiological state in sheep. Public Library of Science 2023-05-09 /pmc/articles/PMC10168572/ /pubmed/37159474 http://dx.doi.org/10.1371/journal.pone.0285338 Text en © 2023 Alon et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Alon, Tamir
Rosov, Alexander
Lifshitz, Lila
Moallem, Uzi
Male fetuses negatively affect the vitality of the litter and the dam’s metabolic and physiological state in multifetal pregnant ewe
title Male fetuses negatively affect the vitality of the litter and the dam’s metabolic and physiological state in multifetal pregnant ewe
title_full Male fetuses negatively affect the vitality of the litter and the dam’s metabolic and physiological state in multifetal pregnant ewe
title_fullStr Male fetuses negatively affect the vitality of the litter and the dam’s metabolic and physiological state in multifetal pregnant ewe
title_full_unstemmed Male fetuses negatively affect the vitality of the litter and the dam’s metabolic and physiological state in multifetal pregnant ewe
title_short Male fetuses negatively affect the vitality of the litter and the dam’s metabolic and physiological state in multifetal pregnant ewe
title_sort male fetuses negatively affect the vitality of the litter and the dam’s metabolic and physiological state in multifetal pregnant ewe
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168572/
https://www.ncbi.nlm.nih.gov/pubmed/37159474
http://dx.doi.org/10.1371/journal.pone.0285338
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