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Selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tACS)

Transcranial alternating current stimulation (tACS) represents a promising non-invasive treatment for an increasingly wide range of neurological and neuropsychiatric disorders. The ability to use periodically oscillating electric fields to non-invasively engage neural dynamics opens up the possibili...

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Detalles Bibliográficos
Autores principales: Pariz, Aref, Trotter, Daniel, Hutt, Axel, Lefebvre, Jeremie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168590/
https://www.ncbi.nlm.nih.gov/pubmed/37104534
http://dx.doi.org/10.1371/journal.pcbi.1010736
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author Pariz, Aref
Trotter, Daniel
Hutt, Axel
Lefebvre, Jeremie
author_facet Pariz, Aref
Trotter, Daniel
Hutt, Axel
Lefebvre, Jeremie
author_sort Pariz, Aref
collection PubMed
description Transcranial alternating current stimulation (tACS) represents a promising non-invasive treatment for an increasingly wide range of neurological and neuropsychiatric disorders. The ability to use periodically oscillating electric fields to non-invasively engage neural dynamics opens up the possibility of recruiting synaptic plasticity and to modulate brain function. However, despite consistent reports about tACS clinical effectiveness, strong state-dependence combined with the ubiquitous heterogeneity of cortical networks collectively results in high outcome variability. Introducing variations in intrinsic neuronal timescales, we explored how such heterogeneity influences stimulation-induced change in synaptic connectivity. We examined how spike timing dependent plasticity, at the level of cells, intra- and inter-laminar cortical networks, can be selectively and preferentially engaged by periodic stimulation. Using leaky integrate-and-fire neuron models, we analyzed cortical circuits comprised of multiple cell-types, alongside superficial multi-layered networks expressing distinct layer-specific timescales. Our results show that mismatch in neuronal timescales within and/or between cells—and the resulting variability in excitability, temporal integration properties and frequency tuning—enables selective and directional control on synaptic connectivity by tACS. Our work provides new vistas on how to recruit neural heterogeneity to guide brain plasticity using non-invasive stimulation paradigms.
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spelling pubmed-101685902023-05-10 Selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tACS) Pariz, Aref Trotter, Daniel Hutt, Axel Lefebvre, Jeremie PLoS Comput Biol Research Article Transcranial alternating current stimulation (tACS) represents a promising non-invasive treatment for an increasingly wide range of neurological and neuropsychiatric disorders. The ability to use periodically oscillating electric fields to non-invasively engage neural dynamics opens up the possibility of recruiting synaptic plasticity and to modulate brain function. However, despite consistent reports about tACS clinical effectiveness, strong state-dependence combined with the ubiquitous heterogeneity of cortical networks collectively results in high outcome variability. Introducing variations in intrinsic neuronal timescales, we explored how such heterogeneity influences stimulation-induced change in synaptic connectivity. We examined how spike timing dependent plasticity, at the level of cells, intra- and inter-laminar cortical networks, can be selectively and preferentially engaged by periodic stimulation. Using leaky integrate-and-fire neuron models, we analyzed cortical circuits comprised of multiple cell-types, alongside superficial multi-layered networks expressing distinct layer-specific timescales. Our results show that mismatch in neuronal timescales within and/or between cells—and the resulting variability in excitability, temporal integration properties and frequency tuning—enables selective and directional control on synaptic connectivity by tACS. Our work provides new vistas on how to recruit neural heterogeneity to guide brain plasticity using non-invasive stimulation paradigms. Public Library of Science 2023-04-27 /pmc/articles/PMC10168590/ /pubmed/37104534 http://dx.doi.org/10.1371/journal.pcbi.1010736 Text en © 2023 Pariz et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pariz, Aref
Trotter, Daniel
Hutt, Axel
Lefebvre, Jeremie
Selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tACS)
title Selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tACS)
title_full Selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tACS)
title_fullStr Selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tACS)
title_full_unstemmed Selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tACS)
title_short Selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tACS)
title_sort selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tacs)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168590/
https://www.ncbi.nlm.nih.gov/pubmed/37104534
http://dx.doi.org/10.1371/journal.pcbi.1010736
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