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Polyethylene Glycol 20k. Does It Fluoresce?
[Image: see text] Polyethylene glycol (PEG) is a polyether compound commonly used in biological research and medicine because it is biologically inert. This simple polymer exists in variable chain lengths (and molecular weights). As they are devoid of any contiguous π-system, PEGs are expected to la...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168656/ https://www.ncbi.nlm.nih.gov/pubmed/37180871 http://dx.doi.org/10.1021/acsomega.3c01124 |
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author | Laatsch, Bethany F. Brandt, Michael Finke, Brianna Fossum, Carl J. Wackett, Miles J. Lowater, Harrison R. Narkiewicz-Jodko, Alex Le, Christine N. Yang, Thao Glogowski, Elizabeth M. Bailey-Hartsel, Scott C. Bhattacharyya, Sudeep Hati, Sanchita |
author_facet | Laatsch, Bethany F. Brandt, Michael Finke, Brianna Fossum, Carl J. Wackett, Miles J. Lowater, Harrison R. Narkiewicz-Jodko, Alex Le, Christine N. Yang, Thao Glogowski, Elizabeth M. Bailey-Hartsel, Scott C. Bhattacharyya, Sudeep Hati, Sanchita |
author_sort | Laatsch, Bethany F. |
collection | PubMed |
description | [Image: see text] Polyethylene glycol (PEG) is a polyether compound commonly used in biological research and medicine because it is biologically inert. This simple polymer exists in variable chain lengths (and molecular weights). As they are devoid of any contiguous π-system, PEGs are expected to lack fluorescence properties. However, recent studies suggested the occurrence of fluorescence properties in non-traditional fluorophores like PEGs. Herein, a thorough investigation has been conducted to explore if PEG 20k fluoresces. Results of this combined experimental and computational study suggested that although PEG 20k could exhibit “through-space” delocalization of lone pairs of electrons in aggregates/clusters, formed via intermolecular and intramolecular interactions, the actual contributor of fluorescence between 300 and 400 nm is the stabilizer molecule, i.e., 3-tert-butyl-4-hydroxyanisole present in the commercially available PEG 20k. Therefore, the reported fluorescence properties of PEG should be taken with a grain of salt, warranting further investigation. |
format | Online Article Text |
id | pubmed-10168656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-101686562023-05-10 Polyethylene Glycol 20k. Does It Fluoresce? Laatsch, Bethany F. Brandt, Michael Finke, Brianna Fossum, Carl J. Wackett, Miles J. Lowater, Harrison R. Narkiewicz-Jodko, Alex Le, Christine N. Yang, Thao Glogowski, Elizabeth M. Bailey-Hartsel, Scott C. Bhattacharyya, Sudeep Hati, Sanchita ACS Omega [Image: see text] Polyethylene glycol (PEG) is a polyether compound commonly used in biological research and medicine because it is biologically inert. This simple polymer exists in variable chain lengths (and molecular weights). As they are devoid of any contiguous π-system, PEGs are expected to lack fluorescence properties. However, recent studies suggested the occurrence of fluorescence properties in non-traditional fluorophores like PEGs. Herein, a thorough investigation has been conducted to explore if PEG 20k fluoresces. Results of this combined experimental and computational study suggested that although PEG 20k could exhibit “through-space” delocalization of lone pairs of electrons in aggregates/clusters, formed via intermolecular and intramolecular interactions, the actual contributor of fluorescence between 300 and 400 nm is the stabilizer molecule, i.e., 3-tert-butyl-4-hydroxyanisole present in the commercially available PEG 20k. Therefore, the reported fluorescence properties of PEG should be taken with a grain of salt, warranting further investigation. American Chemical Society 2023-04-06 /pmc/articles/PMC10168656/ /pubmed/37180871 http://dx.doi.org/10.1021/acsomega.3c01124 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Laatsch, Bethany F. Brandt, Michael Finke, Brianna Fossum, Carl J. Wackett, Miles J. Lowater, Harrison R. Narkiewicz-Jodko, Alex Le, Christine N. Yang, Thao Glogowski, Elizabeth M. Bailey-Hartsel, Scott C. Bhattacharyya, Sudeep Hati, Sanchita Polyethylene Glycol 20k. Does It Fluoresce? |
title | Polyethylene Glycol 20k. Does It Fluoresce? |
title_full | Polyethylene Glycol 20k. Does It Fluoresce? |
title_fullStr | Polyethylene Glycol 20k. Does It Fluoresce? |
title_full_unstemmed | Polyethylene Glycol 20k. Does It Fluoresce? |
title_short | Polyethylene Glycol 20k. Does It Fluoresce? |
title_sort | polyethylene glycol 20k. does it fluoresce? |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168656/ https://www.ncbi.nlm.nih.gov/pubmed/37180871 http://dx.doi.org/10.1021/acsomega.3c01124 |
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