Cargando…

Gastric cancer cell-originated small extracellular vesicle induces metabolic reprogramming of BM-MSCs through ERK-PPARγ-CPT1A signaling to potentiate lymphatic metastasis

Tumor microenvironment and metabolic reprogramming are critical for tumor metastasis. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are widely involved in the formation of tumor microenvironment and present oncogenic phenotypes to facilitate lymph node metastasis (LNM) in response to small ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Jiaying, Wang, Xiang, Wen, Jing, Zhao, Xinxin, Wu, Chen, Wang, Lin, Cao, Xiaoli, Dong, Haibo, Xu, Xuejing, Huang, Feng, Zhu, Wei, Wang, Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169337/ https://www.ncbi.nlm.nih.gov/pubmed/37158903 http://dx.doi.org/10.1186/s12935-023-02935-5

Ejemplares similares

SENP3-Mediated PPARγ2 DeSUMOylation in BM-MSCs Potentiates Glucocorticoid-Induced Osteoporosis by Promoting Adipogenesis and Weakening Osteogenesis
por: Zhang, Yongxing, et al.
Publicado: (2021)

GC‑MSC‑derived circ_0024107 promotes gastric cancer cell lymphatic metastasis via fatty acid oxidation metabolic reprogramming mediated by the miR‑5572/6855‑5p/CPT1A axis
por: Wang, Lin, et al.
Publicado: (2023)

Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
por: Yang, Chunjuan, et al.
Publicado: (2021)

NMDA receptor activation inhibits the protective effect of BM-MSCs on bleomycin-induced lung epithelial cell damage by inhibiting ERK signaling and the paracrine factor HGF
por: Peng, Xiangping, et al.
Publicado: (2019)

Hyperleukocytic Acute Leukemia Circulating Exosomes Regulate HSCs and BM-MSCs
por: Yang, Yanmei, et al.
Publicado: (2021)

AD-MSCs and BM-MSCs Ameliorating Effects on The Metabolic and Hepato-renal Abnormalities in Type 1 Diabetic Rats
por: El-Sawah, Shady G., et al.
Publicado: (2022)

Exosomal CD44 Transmits Lymph Node Metastatic Capacity Between Gastric Cancer Cells via YAP-CPT1A-Mediated FAO Reprogramming
por: Wang, Mei, et al.
Publicado: (2022)

BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling
por: Zuo, Rui, et al.
Publicado: (2019)

NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis
por: Li, Xiaohong, et al.
Publicado: (2018)

Role of Ox-PAPCs in the Differentiation of Mesenchymal Stem Cells (MSCs) and Runx2 and PPARγ2 Expression in MSCs-Like of Osteoporotic Patients
por: Valenti, Maria Teresa, et al.
Publicado: (2011)

BM-MSCs differentiated to chondrocytes for treatment of full-thickness cartilage defect of the knee
por: Mardones, Rodrigo, et al.
Publicado: (2020)

Retracted: Hyperleukocytic Acute Leukemia Circulating Exosomes Regulate HSCs and BM-MSCs
por: Healthcare Engineering, Journal of
Publicado: (2022)

Correction to: BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling
por: Zuo, Rui, et al.
Publicado: (2020)

Glycolytic reprogramming in macrophages and MSCs during inflammation
por: Li, Xueping, et al.
Publicado: (2023)

Pretreatment with G-CSF Could Enhance the Antifibrotic Effect of BM-MSCs on Pulmonary Fibrosis
por: Zhao, Feiyan, et al.
Publicado: (2019)

The Effects of Platelet-Rich and Platelet-Poor Plasma on Biological Characteristics of BM-MSCs In Vitro
por: Zhang, Jiahui, et al.
Publicado: (2020)

Epigenetic Histone Methylation of PPARγ and CPT1A Signaling Contributes to Betahistine Preventing Olanzapine-Induced Dyslipidemia
por: Su, Yueqing, et al.
Publicado: (2023)

Pan LF-ELISA using BmR1 and BmSXP recombinant antigens for detection of lymphatic filariasis
por: Abdul Rahman, Rohana, et al.
Publicado: (2007)

An Erk/Cdk5 axis controls the diabetogenic actions of PPARγ
por: Banks, Alexander S., et al.
Publicado: (2014)

PPARγ Regulates Triclosan Induced Placental Dysfunction
por: Li, Jing, et al.
Publicado: (2021)

BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction
por: Xu, Yan-nan, et al.
Publicado: (2023)

Extracellular vesicles derived from DFO-preconditioned canine AT-MSCs reprogram macrophages into M2 phase
por: Park, Su-Min, et al.
Publicado: (2021)

Loss of A20 in BM-MSCs regulates the Th17/Treg balance in Rheumatoid Arthritis
por: Feng, Zhuan, et al.
Publicado: (2018)

An Effect of Cyclosporin A in a Treatment of Temporal Bone Defect Using hBM-MSCs
por: Skoloudik, Lukas, et al.
Publicado: (2022)

Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers
por: Loft, Anne, et al.
Publicado: (2015)

lncRNA HHIP-AS1/HHIP modulates osteogenic differentiation of BM-MSCs by regulating Hedgehog signaling pathway
por: Yin, Xin-Hua, et al.
Publicado: (2022)

Induced Neurodifferentiation of hBM-MSCs through Activation of the ERK/CREB Pathway via Pulsed Electromagnetic Fields and Physical Stimulation Promotes Neurogenesis in Cerebral Ischemic Models
por: Park, Hee-Jung, et al.
Publicado: (2022)

Effects of Pulsed 2.856 GHz Microwave Exposure on BM-MSCs Isolated from C57BL/6 Mice
por: Wang, Changzhen, et al.
Publicado: (2015)

BM-MSCs promote prostate cancer progression via the conversion of normal fibroblasts to cancer-associated fibroblasts
por: WEN, SIMENG, et al.
Publicado: (2015)

Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs
por: Wang, Kanbin, et al.
Publicado: (2022)

Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis
por: Zhao, Xige, et al.
Publicado: (2020)

Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity
por: Caruso, Joseph A., et al.
Publicado: (2023)

Serum regulates adipogenesis of mesenchymal stem cells via MEK/ERK-dependent PPARγ expression and phosphorylation
por: Wu, Ling, et al.
Publicado: (2010)

Exosomes from BM-MSCs increase the population of CSCs via transfer of miR-142-3p
por: Li, Hongdan, et al.
Publicado: (2018)

Quantitative proteomics reveals Polygonum perfoliatum L. ameliorates hepatic steatosis by promoting PPARs/CPT1A/CPT2-mediated fatty acid β-oxidation
por: Liu, Guanjie, et al.
Publicado: (2023)

Scaffold-Based Pan-Agonist Design for the PPARα, PPARβ and PPARγ Receptors
por: Zhang, Li-Song, et al.
Publicado: (2012)

Demyelination in Multiple Sclerosis: Reprogramming Energy Metabolism and Potential PPARγ Agonist Treatment Approaches
por: Vallée, Alexandre, et al.
Publicado: (2018)

Bone Marrow Mesenchymal Stem Cells (BM-MSCs) Improve Heart Function in Swine Myocardial Infarction Model through Paracrine Effects
por: Cai, Min, et al.
Publicado: (2016)

Exosomes from BM-MSCs promote acute myeloid leukemia cell proliferation, invasion and chemoresistance via upregulation of S100A4
por: Lyu, Tianxin, et al.
Publicado: (2021)

IRF4 suppresses osteogenic differentiation of BM-MSCs by transcriptionally activating miR-636/DOCK9 axis
por: Zhang, Xuepu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_eh2agqk9sr0f8kosh6i019ueto