Cargando…

Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer’s disease but not Lewy body dementias

BACKGROUND: Chronically dysregulated neuroinflammation has been implicated in neurodegenerative dementias, with separate studies reporting increased brain levels of inflammatory mediators and gliosis in Alzheimer’s disease (AD) as well as in Lewy body dementias (LBD). However, it is unclear whether...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chai, Yuek Ling, Lee, Jasinda H., Chong, Joyce R., Ballard, Clive, Francis, Paul T., Kennedy, Brian K., Arumugam, Thiruma V., Chen, Christopher P., Aarsland, Dag, Lai, Mitchell K. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169342/ https://www.ncbi.nlm.nih.gov/pubmed/37158957 http://dx.doi.org/10.1186/s12974-023-02789-8

Ejemplares similares

Decreased DHA‐containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble Aβ(42), phosphorylated α‐synuclein, and synaptopathology
por: Chong, Joyce R., et al.
Publicado: (2023)

Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias
por: Xing, Huayang, et al.
Publicado: (2016)

Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias
por: Howlett, David R., et al.
Publicado: (2014)

Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers
por: Gibson, Lucy L., et al.
Publicado: (2023)

Treatment effect of memantine on survival in dementia with Lewy bodies and Parkinson's disease with dementia: a prospective study
por: Stubendorff, Kajsa, et al.
Publicado: (2014)

An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias
por: Datta, Arnab, et al.
Publicado: (2017)

Hospitalization in people with dementia with Lewy bodies: Frequency, duration, and cost implications
por: Mueller, Christoph, et al.
Publicado: (2017)

((123)I)FP-CIT SPECT in suspected dementia with Lewy bodies: a longitudinal case study
por: Siepel, Françoise J, et al.
Publicado: (2013)

Dementia with Lewy Bodies Drug Therapies in Clinical Trials: Systematic Review up to 2022
por: Abdelnour, Carla, et al.
Publicado: (2023)

Isoform‐specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer's disease and Lewy body dementias
por: Low, Clara Y. B., et al.
Publicado: (2021)

Mental health of people living with dementia in care homes during COVID-19 pandemic
por: Velayudhan, Latha, et al.
Publicado: (2020)

Cognitive decline in dementia with Lewy bodies: a 5-year prospective cohort study
por: Rongve, A, et al.
Publicado: (2016)

Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia
por: Vallortigara, Julie, et al.
Publicado: (2014)

The Impact of Autonomic Dysfunction on Survival in Patients with Dementia with Lewy Bodies and Parkinson's Disease with Dementia
por: Stubendorff, Kajsa, et al.
Publicado: (2012)

Clinical and Neuropsychological Differences between Mild Parkinson's Disease Dementia and Dementia with Lewy Bodies
por: Petrova, Mariya, et al.
Publicado: (2015)

Late‐life onset psychotic symptoms and incident cognitive impairment in people without dementia: Modification by genetic risk for Alzheimer's disease
por: Creese, Byron, et al.
Publicado: (2023)

Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia
por: Alghamdi, Amani, et al.
Publicado: (2017)

Antipsychotic use in dementia: the relationship between neuropsychiatric symptom profiles and adverse outcomes
por: Mueller, Christoph, et al.
Publicado: (2020)

Demography, diagnostics, and medication in dementia with Lewy bodies and Parkinson’s disease with dementia: data from the Swedish Dementia Quality Registry (SveDem)
por: Fereshtehnejad, Seyed-Mohammad, et al.
Publicado: (2013)

Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial
por: Husebo, Bettina S, et al.
Publicado: (2011)

Structural synaptic signatures of Alzheimer's disease and dementia with Lewy bodies in the male brain
por: Glebov, Oleg O., et al.
Publicado: (2022)

Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates
por: Mulugeta, Ezra, et al.
Publicado: (2011)

Research criteria for the diagnosis of prodromal dementia with Lewy bodies
por: McKeith, Ian G., et al.
Publicado: (2020)

White Matter Hyperintensities in Mild Lewy Body Dementia
por: Oppedal, K., et al.
Publicado: (2012)

Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort
por: Berge, Guro, et al.
Publicado: (2014)

A Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer’s Disease
por: Breitve, Monica H., et al.
Publicado: (2018)

Psychiatric and neuropsychiatric syndromes and COVID-19
por: Velayudhan, Latha, et al.
Publicado: (2020)

A systematic review of cognitive decline in dementia with Lewy bodies versus Alzheimer’s disease
por: Breitve, Monica H, et al.
Publicado: (2014)

Efficacy and Safety of Analgesic Treatment for Depression in People with Advanced Dementia: Randomised, Multicentre, Double-Blind, Placebo-Controlled Trial (DEP.PAIN.DEM)
por: Erdal, Ane, et al.
Publicado: (2018)

A longitudinal study of anxiety and cognitive decline in dementia with Lewy bodies and Alzheimer’s disease
por: Breitve, Monica H., et al.
Publicado: (2016)

Comorbidity profile in dementia with Lewy bodies versus Alzheimer’s disease: a linkage study between the Swedish Dementia Registry and the Swedish National Patient Registry
por: Fereshtehnejad, Seyed-Mohammad, et al.
Publicado: (2014)

Apathy is associated with faster global cognitive decline and early nursing home admission in dementia with Lewy bodies
por: Breitve, Monica H., et al.
Publicado: (2018)

Dementia with Lewy bodies research consortia: A global perspective from the ISTAART Lewy Body Dementias Professional Interest Area working group
por: D'Antonio, Fabrizia, et al.
Publicado: (2021)

Tolerability of buprenorphine transdermal system in nursing home patients with advanced dementia: a randomized, placebo-controlled trial (DEP.PAIN.DEM)
por: Erdal, Ane, et al.
Publicado: (2018)

Body mass index trajectories and associations with cognitive decline in people with Lewy body dementia and Alzheimer's disease
por: Borda, Miguel G., et al.
Publicado: (2022)

Association Between Amygdala Volume and Trajectories of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia With Lewy Bodies
por: Jaramillo-Jimenez, Alberto, et al.
Publicado: (2021)

Sex differences in grey matter networks in dementia with Lewy bodies
por: Habich, Annegret, et al.
Publicado: (2023)

Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011–2022 Update
por: Rogowska, Marianna, et al.
Publicado: (2022)

RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus
por: O’Brien, John T., et al.
Publicado: (2022)

Prodromal Dementia With Lewy Bodies and Recurrent Panic Attacks as the First Symptom: A Case Report
por: Jaramillo-Jimenez, Alberto, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3hm441b0vu516vdedkn9gh8u0r